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    Slc52a2 solute carrier protein 52, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 52710, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Slc52a2provided by MGI
    Official Full Name
    solute carrier protein 52, member 2provided by MGI
    Primary source
    MGI:MGI:1289288
    See related
    Ensembl:ENSMUSG00000022560 AllianceGenome:MGI:1289288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAR2; RFT1; Rfvt2; mRFT1; GPCR42; Gpr172b; D15Ertd747e; 2010003P03Rik
    Summary
    Enables riboflavin transmembrane transporter activity. Involved in flavin adenine dinucleotide biosynthetic process and riboflavin metabolic process. Is active in plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 2 and riboflavin deficiency. Orthologous to several human genes including SLC52A2 (solute carrier family 52 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 16.9), small intestine adult (RPKM 12.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc52a2 in Genome Data Viewer
    Location:
    15 D3; 15 36.04 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76422994..76432078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76538814..76547878)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 249 Neighboring gene STARR-positive B cell enhancer ABC_E3144 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene predicted gene, 35739 Neighboring gene STARR-positive B cell enhancer ABC_E9913 Neighboring gene aarF domain containing kinase 5 Neighboring gene cleavage and polyadenylation specific factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Complete Deletion of Slc52a2 Causes Embryonic Lethality in Mice. Jin C, et al. Biol Pharm Bull, 2021. PMID 33518683
    2. Involvement of riboflavin transporter RFVT2/Slc52a2 in hepatic homeostasis of riboflavin in mice. Yao Y, et al. Eur J Pharmacol, 2013 Aug 15. PMID 23911957
    3. SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation. Intoh A, et al. Hum Mol Genet, 2016 May 1. PMID 26976849, Free PMC Article
    4. Riboflavin uptake transporter Slc52a2 (RFVT2) is upregulated in the mouse mammary gland during lactation. Wu AM, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Apr 1. PMID 26791833
    5. Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice. Jin C, et al. Sci Rep, 2020 Oct 28. PMID 33116204, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Complete Deletion of Slc52a2 Causes Embryonic Lethality in Mice.
      Title: Complete Deletion of Slc52a2 Causes Embryonic Lethality in Mice.
    2. mRFVT2 was involved in hepatic riboflavin homeostasis
      Title: Involvement of riboflavin transporter RFVT2/Slc52a2 in hepatic homeostasis of riboflavin in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (2) 
    • Targeted (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4-hydroxybutyrate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4-hydroxybutyrate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables riboflavin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables riboflavin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables riboflavin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables riboflavin transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in flavin adenine dinucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in flavin adenine dinucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in riboflavin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in riboflavin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in riboflavin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in riboflavin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 52, riboflavin transporter, member 2
    Names
    G protein-coupled receptor 172B
    PERV-A receptor 2 homolog
    porcine endogenous retrovirus A receptor 2 homolog
    riboflavin transporter 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029643.4 → NP_083919.1  solute carrier family 52, riboflavin transporter, member 2

      See identical proteins and their annotated locations for NP_083919.1

      Status: VALIDATED

      Source sequence(s)
      AC157566, AK029579, BY148057
      Consensus CDS
      CCDS27575.1
      UniProtKB/Swiss-Prot
      Q8CCV8, Q9D8F3
      Related
      ENSMUSP00000023220.9, ENSMUST00000023220.10
      Conserved Domains (1) summary
      pfam06237
      Location:282 → 376
      DUF1011; Protein of unknown function (DUF1011)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76422994..76432078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521151.5 → XP_006521214.1  solute carrier family 52, riboflavin transporter, member 2 isoform X1

      See identical proteins and their annotated locations for XP_006521214.1

      UniProtKB/Swiss-Prot
      Q8CCV8, Q9D8F3
      Conserved Domains (1) summary
      pfam06237
      Location:282 → 376
      DUF1011; Protein of unknown function (DUF1011)

    RNA

    1. XR_004938852.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8F3.1 GenPept UniProtKB/Swiss-Prot:Q9D8F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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