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    HUL4 putative E3 ubiquitin-protein ligase HUL4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HUL4
    Official Full Name
    putative E3 ubiquitin-protein ligase HUL4
    Primary source
    SGD:S000003797
    Locus tag
    YJR036C
    See related
    AllianceGenome:SGD:S000003797; FungiDB:YJR036C; VEuPathDB:YJR036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in prospore membrane. Part of TRAMP complex. Orthologous to human HECTD2 (HECT domain E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HUL4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (500713..503391, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Pet191p Neighboring gene DNA-dependent ATPase RAD26 Neighboring gene Mlo127p Neighboring gene Gef1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional domains of the Rsp5 ubiquitin-protein ligase. Wang G, et al. Mol Cell Biol, 1999 Jan. PMID 9858558, Free PMC Article
    2. Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization. La Ferla M, et al. Mutat Res, 2015 Apr. PMID 25779917
    3. Enhanced membrane fusion in sterol-enriched vacuoles bypasses the Vrp1p requirement. Tedrick K, et al. Mol Biol Cell, 2004 Oct. PMID 15254266, Free PMC Article
    4. Ribosome-associated quality control mediates degradation of the premature translation termination product Orf1p of ODC antizyme mRNA. Pradhan AK, et al. FEBS Lett, 2021 Aug. PMID 34109626
    5. Analysis of nitrated proteins in Saccharomyces cerevisiae involved in mating signal transduction. Kang JW, et al. Proteomics, 2015 Jan. PMID 25204828

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRAMP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    putative E3 ubiquitin-protein ligase HUL4
    NP_012570.3
    • Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      500713..503391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181694.3 → NP_012570.3  TPA: putative E3 ubiquitin-protein ligase HUL4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012570.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWK9, P40985
      UniProtKB/TrEMBL
      A6ZPZ7, C7GTB8, G2WH42, N1P122
      Conserved Domains (1) summary
      COG5021
      Location:1 → 892
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40985.2

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