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    HFL1 Hfl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HFL1
    Official Full Name
    Hfl1p
    Primary source
    SGD:S000001759
    Locus tag
    YKR051W
    See related
    AllianceGenome:SGD:S000001759; FungiDB:YKR051W; VEuPathDB:YKR051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Involved in protein targeting to vacuolar membrane. Located in endoplasmic reticulum. Is active in vacuolar membrane. Orthologous to several human genes including TMEM184C (transmembrane protein 184C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HFL1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (530946..532202)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative redox protein Neighboring gene Trk2p Neighboring gene Fe(2+) transporter Neighboring gene sphinganine kinase YSR3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane recruitment of Atg8 by Hfl1 facilitates turnover of vacuolar membrane proteins in yeast cells approaching stationary phase. He CW, et al. BMC Biol, 2021 Jun 4. PMID 34088313, Free PMC Article
    2. Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein. Liu XM, et al. Elife, 2018 Nov 19. PMID 30451685, Free PMC Article
    3. Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. She R, et al. Proc Natl Acad Sci U S A, 2017 Apr 4. PMID 28325876, Free PMC Article
    4. Complete DNA sequence of yeast chromosome XI. Dujon B, et al. Nature, 1994 Jun 2. PMID 8196765
    5. A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Finnigan GC, et al. Genetics, 2011 Mar. PMID 21196517, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to vacuolar membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hfl1p
    NP_012977.3
    • Vacuole membrane protein that interacts with Atg8p; functions in the vacuolar membrane recruitment of Atg8p to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT), a general degradation process for vacuolar integral membrane proteins when cells enter stationary phase; null mutant is defective in stationary phase-induced vacuolar microdomain formation; homolog of S. pombe hfl1; homolog of human TMEM184

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      530946..532202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179841.3 → NP_012977.3  TPA: Hfl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012977.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXB2, P36142
      UniProtKB/TrEMBL
      A7A011, B5VMJ8, C7GNL4, G2WI79, N1P841
      Conserved Domains (1) summary
      pfam03619
      Location:14 → 267
      Solute_trans_a; Organic solute transporter Ostalpha
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36142.1

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