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    BAR1 aspartyl protease BAR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BAR1
    Official Full Name
    aspartyl protease BAR1
    Primary source
    SGD:S000001277
    Locus tag
    YIL015W
    See related
    AllianceGenome:SGD:S000001277; FungiDB:YIL015W; VEuPathDB:YIL015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SST1
    Summary
    Enables aspartic-type endopeptidase activity. Involved in cellular response to pheromone; conjugation with cellular fusion; and peptide catabolic process. Located in extracellular region and fungal-type cell wall. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BAR1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (322342..324105)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene glucose-induced degradation complex subunit VID28 Neighboring gene Snl1p Neighboring gene tRNA-Asp Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recovery of S. cerevisiae a cells from G1 arrest by alpha factor pheromone requires endopeptidase action. Ciejek E, et al. Cell, 1979 Nov. PMID 391400
    2. Properties of Barrier, a novel Saccharomyces cerevisiae acid protease. Nath R. Biochimie, 1993. PMID 8364097
    3. Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Chan RK, et al. Mol Cell Biol, 1982 Jan. PMID 7050665, Free PMC Article
    4. Periplasmic Bar1 protease of Saccharomyces cerevisiae is active before reaching its extracellular destination. Ballensiefen W, et al. Eur J Biochem, 1997 Jul 1. PMID 9249020
    5. Somatostatin receptors and regulation of cell proliferation. Bousquet C, et al. Dig Liver Dis, 2004 Feb. PMID 15077905

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the effect of sequence-directed nucleosome disruption on cell-type-specific repression of BAR1 by alpha2/Mcm1 in the yeast genome.
      Title: Effect of sequence-directed nucleosome disruption on cell-type-specific repression by alpha2/Mcm1 in the yeast genome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in conjugation with cellular fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aspartyl protease BAR1
    NP_012249.1
    • Aspartyl protease secreted to periplasmic space of mating type a cell; helps cells monitor availability of mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      322342..324105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179365.1 → NP_012249.1  TPA: aspartyl protease BAR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012249.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVR4, P12630
      UniProtKB/TrEMBL
      B3LTM3, B5VKS5, C7GSF7, C8ZAN5, N1P965
      Conserved Domains (1) summary
      cd05474
      Location:43 → 395
      SAP_like; SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12630.1

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