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    MAK10 Mak10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856657, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAK10
    Official Full Name
    Mak10p
    Primary source
    SGD:S000000779
    Locus tag
    YEL053C
    See related
    AllianceGenome:SGD:S000000779; FungiDB:YEL053C; VEuPathDB:YEL053C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NAA35
    Summary
    Contributes to peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation and macroautophagy. Located in cytoplasm. Part of NatC complex. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MAK10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (53901..56102, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L12A Neighboring gene Afg1p Neighboring gene H(+)-transporting V1 sector ATPase subunit D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAK10, a glucose-repressible gene necessary for replication of a dsRNA virus of Saccharomyces cerevisiae, has T cell receptor alpha-subunit motifs. Lee YJ, et al. Genetics, 1992 Sep. PMID 1398065, Free PMC Article
    2. Suppression of chromosomal mutations affecting M1 virus replication in Saccharomyces cerevisiae by a variant of a viral RNA segment (L-A) that encodes coat protein. Uemura H, et al. Mol Cell Biol, 1988 Feb. PMID 3280972, Free PMC Article
    3. L-A double-stranded RNA viruslike particle replication cycle in Saccharomyces cerevisiae: particle maturation in vitro and effects of mak10 and pet18 mutations. Fujimura T, et al. Mol Cell Biol, 1987 Jan. PMID 3550421, Free PMC Article
    4. [HOK], a new yeast non-Mendelian trait, enables a replication-defective killer plasmid to be maintained. Wickner RB, et al. Genetics, 1982 Feb. PMID 7049830, Free PMC Article
    5. Two biochemically and genetically different forms of L dsRNA of Saccharomyces cerevisiae exist: One form, L2, is correlated. El-Sherbeini M, et al. Curr Genet, 1983 Mar. PMID 24173120

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to peptide alpha-N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mak10p
    NP_010861.3
    • Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; human NatC ortholog, Naa35, requires co-expression of the human catalytic subunit, Naa30, to functionally complement the null allele

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      53901..56102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178868.3 → NP_010861.3  TPA: Mak10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010861.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLJ7, Q02197
      UniProtKB/TrEMBL
      B3LRW5, B5VH84, G2WCI1, N1P549
      Conserved Domains (1) summary
      pfam04112
      Location:35 → 193
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02197.1

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