GLY1 threonine aldolase GLY1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GLY1
Official Full Name: threonine aldolase GLY1
Primary source: SGD:S000000772
Locus tag: YEL046C
See related: AllianceGenome:SGD:S000000772; FungiDB:YEL046C; VEuPathDB:YEL046C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables L-allo-threonine aldolase activity. Involved in glycine biosynthetic process and threonine catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GLY1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (67629..68792, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-allo-threonine aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-allo-threonine aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-allo-threonine aldolase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables threonine aldolase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in threonine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in threonine catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: threonine aldolase GLY1

NP_010868.1

EC 4.1.2.48

Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

67629..68792 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178861.1 → NP_010868.1 TPA: threonine aldolase GLY1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010868.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLK4, P32615, P37303

UniProtKB/TrEMBL

B3LRX1, B5VH89, C8Z6U8

Conserved Domains (1) summary

cd06502
Location:16 → 346

TA_like; Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a ...