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Pparg peroxisome proliferator-activated receptor gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 25664, updated on 27-Nov-2024

Summary

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Official Symbol: Ppargprovided by RGD
Official Full Name: peroxisome proliferator-activated receptor gammaprovided by RGD
Primary source: RGD:3371
See related: EnsemblRapid:ENSRNOG00000008839 AllianceGenome:RGD:3371
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PPARgamma2
Summary: Enables several functions, including nuclear estrogen receptor binding activity; protein phosphatase binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to hyperoxia; cellular response to prostaglandin E stimulus; and positive regulation of cell differentiation. Acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of connective tissue replacement involved in inflammatory response wound healing; and positive regulation of adiponectin secretion. Located in perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); glomerulosclerosis; pancreatitis; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 110.5), Adrenal (RPKM 103.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Pparg in Genome Data Viewer

Location:: 4q42

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (150095743..150221104)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (148423102..148548471)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (147274055..147399383)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crosstalk relationship between adiponectin receptors, PPAR-gamma and alpha-adrenoceptors in renal vasculature of diabetic WKYs.
Title: Crosstalk relationship between adiponectin receptors, PPAR-γ and α-adrenoceptors in renal vasculature of diabetic WKYs.
SMYD2-Methylated PPARgamma Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy.
Title: SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy.
PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis.
Title: PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis.
PPARgamma alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Title: PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-gamma axis.
Title: Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis.
DNMT3a-mediated methylation of PPARgamma promote intervertebral disc degeneration by regulating the NF-kappaB pathway.
Title: DNMT3a-mediated methylation of PPARγ promote intervertebral disc degeneration by regulating the NF-κB pathway.
Epigenetic PPARgamma preservation attenuates temporomandibular joint osteoarthritis.
Title: Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis.
PPAR-gamma promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia.
Title: PPAR-γ promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia.
PEDF inhibits LPS-induced acute lung injury in rats and promotes lung epithelial cell survival by upregulating PPAR-gamma.
Title: PEDF inhibits LPS-induced acute lung injury in rats and promotes lung epithelial cell survival by upregulating PPAR-γ.
HIF-1alpha-PPARgamma-mTORC1 signaling pathway-mediated autophagy induces inflammatory response in pancreatic cells in rats with hyperlipidemic acute pancreatitis.
Title: HIF-1α-PPARγ-mTORC1 signaling pathway-mediated autophagy induces inflammatory response in pancreatic cells in rats with hyperlipidemic acute pancreatitis.

Submit: New GeneRIF Correction See all GeneRIFs (392)

General gene information

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Markers

AI229983 (e-PCR)
- UniSTS:249945

AI453959 (e-PCR)
- UniSTS:245913

D4Rat198 (e-PCR), detects polymorphism
- UniSTS:227751

D4Got123 (e-PCR)
- UniSTS:111839

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding domain binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables LBD domain binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables STAT family protein binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables arachidonate binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to lithium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin E stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prostaglandin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cardiac muscle hypertrophy in response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of connective tissue replacement involved in inflammatory response wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pancreatic stellate cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptide hormone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peroxisome proliferator activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of adiponectin secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of low-density lipoprotein receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to caffeine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	ISO Inferred from Sequence Orthology more info
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to linoleic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within white fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect wound healing involved in inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of SUMO ligase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor gamma

Names: PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activator receptor, gamma

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145366.1 → NP_001138838.1 peroxisome proliferator-activated receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001138838.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. Both variants 2 and 3 encode the same protein.

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IKY4

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_001145367.1 → NP_001138839.1 peroxisome proliferator-activated receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001138839.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. Both variants 2 and 3 encode the same protein.

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IKY4

Related

ENSRNOP00000073235.1, ENSRNOT00000082969.3

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_013124.3 → NP_037256.1 peroxisome proliferator-activated receptor gamma isoform 1

See identical proteins and their annotated locations for NP_037256.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1)

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

O88275, Q9QWG0, Q9R197

UniProtKB/TrEMBL

A6IKY3

Related

ENSRNOP00000012137.3, ENSRNOT00000012137.7

Conserved Domains (3) summary

cd06932
Location:237 → 504

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:138 → 221

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:31 → 108

PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

150095743..150221104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237009.5 → XP_006237071.1 peroxisome proliferator-activated receptor gamma isoform X1

See identical proteins and their annotated locations for XP_006237071.1

UniProtKB/TrEMBL

A6IKY4

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
XM_039107130.2 → XP_038963058.1 peroxisome proliferator-activated receptor gamma isoform X1

UniProtKB/TrEMBL

A6IKY4

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
XM_063285619.1 → XP_063141689.1 peroxisome proliferator-activated receptor gamma isoform X2