Slc39a8 solute carrier family 39 member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Slc39a8provided by RGD
Full Name: solute carrier family 39 member 8provided by RGD
Primary source: RGD:1308236
See related: EnsemblRapid:ENSRNOG00000012508 AllianceGenome:RGD:1308236
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables zinc:bicarbonate symporter activity. Involved in monoatomic cation transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn. Orthologous to human SLC39A8 (solute carrier family 39 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 117.5), Kidney (RPKM 104.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (226845686..226992668)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (224171787..224319326)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (241028851..241092584)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-kappaB signaling pathway.
Title: ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Taken together, our results demonstrate that the progressive silencing of Zip8 expression is involved in the acquisition of resistance against Cd in lung cells, representing an adaptive survival mechanism that resists Cd-induced cytotoxicity.
Title: Progressive silencing of the zinc transporter Zip8 (Slc39a8) in chronic cadmium-exposed lung epithelial cells.
Nuclear localization for Zip8 and Zip14 transporters as well as TfR1 was observed in the inner ear of rats.
Title: Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats.
ZIP8 plays a pivotal role in the transport and toxicity of Cd(2+) and Mn(2+) in RBL-2H3 cells.
Title: Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells.
data identify ZIP8 as an iron transport protein that may function in iron metabolism.
Title: ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading.
The high expression of ZIP8, which is known to have affinities for both Cd and Mn, resulted in high accumulation of Cd and Mn.
Title: High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation:bicarbonate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation:bicarbonate symporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation:bicarbonate symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc:bicarbonate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc:bicarbonate symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of arginine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of arginine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in bicarbonate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cadmium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cadmium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cadmium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of cartilage homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cartilage homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular detoxification of cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification of cadmium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cobalt ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of extracellular matrix organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular manganese ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular manganese ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in iron ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of leukocyte adhesion to arterial endothelial cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of leukocyte adhesion to arterial endothelial cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in manganese ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in manganese ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mercury ion transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial manganese ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial manganese ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_negative_effect negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane selenite transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metal cation symporter ZIP8

Names: ZIP-8; solute carrier family 39 (metal ion transporter), member 8; solute carrier family 39 (zinc transporter), member 8; zinc transporter ZIP8; zrt- and Irt-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011952.1 → NP_001011952.1 metal cation symporter ZIP8 precursor

See identical proteins and their annotated locations for NP_001011952.1

Status: PROVISIONAL

Source sequence(s)

BC089844

UniProtKB/Swiss-Prot

Q5FVQ0

UniProtKB/TrEMBL

A6HVY9

Conserved Domains (1) summary

pfam02535
Location:126 → 453

Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

226845686..226992668

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102102.2 → XP_038958030.1 metal cation symporter ZIP8 isoform X1

UniProtKB/Swiss-Prot

Q5FVQ0

UniProtKB/TrEMBL

A6HVY9

Conserved Domains (1) summary

pfam02535
Location:126 → 453

Zip; ZIP Zinc transporter
XM_017590787.3 → XP_017446276.1 metal cation symporter ZIP8 isoform X1

UniProtKB/Swiss-Prot

Q5FVQ0

UniProtKB/TrEMBL

A6HVY9

Conserved Domains (1) summary

pfam02535
Location:126 → 453

Zip; ZIP Zinc transporter
XM_039102104.2 → XP_038958032.1 metal cation symporter ZIP8 isoform X1

UniProtKB/Swiss-Prot

Q5FVQ0

UniProtKB/TrEMBL

A6HVY9

Conserved Domains (1) summary

pfam02535
Location:126 → 453

Zip; ZIP Zinc transporter
XM_006233356.4 → XP_006233418.1 metal cation symporter ZIP8 isoform X1

See identical proteins and their annotated locations for XP_006233418.1

UniProtKB/Swiss-Prot

Q5FVQ0

UniProtKB/TrEMBL

A6HVY9

Related

ENSRNOP00000030977.4, ENSRNOT00000033413.8

Conserved Domains (1) summary

pfam02535
Location:126 → 453

Zip; ZIP Zinc transporter
XM_006233357.4 → XP_006233419.1 metal cation symporter ZIP8 isoform X1

See identical proteins and their annotated locations for XP_006233419.1

UniProtKB/Swiss-Prot

Q5FVQ0

UniProtKB/TrEMBL

A6HVY9

Conserved Domains (1) summary

pfam02535
Location:126 → 453

Zip; ZIP Zinc transporter