Prcp prolylcarboxypeptidase (angiotensinase C) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prcpprovided by MGI
Official Full Name: prolylcarboxypeptidase (angiotensinase C)provided by MGI
Primary source: MGI:MGI:1919711
See related: Ensembl:ENSMUSG00000061119 AllianceGenome:MGI:1919711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PCP; HUMPCP; 2510048K03Rik; 2610104A14Rik
Summary: Predicted to enable dipeptidyl-peptidase activity. Acts upstream of or within several processes, including angiogenesis involved in wound healing; plasma kallikrein-kinin cascade; and regulation of thyroid hormone receptor signaling pathway. Located in basal part of cell and lysosome. Is expressed in several structures, including axial musculature; brain meninges; craniocervical region bone; foregut; and liver lobe. Orthologous to human PRCP (prolylcarboxypeptidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 12.8), placenta adult (RPKM 12.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 51.64 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (92524461..92583789)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (92875253..92934581)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRCP in Agouti-related peptide neurons contributes to the modulation of alpha-MSH degradation, food intake and body weight.
Title: Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight.
Prolylcarboxypeptidase (PRCP) converts AngII to Ang (1-7) but only at an acidic pH. Global PRCP deficiency causes heart and kidney alterations and a moderate rise in BP. PRCP is abundant in the kidney collecting tubules, where the prevailing pH is low. In collecting tubules, PRCP deficiency could result in impaired AngII degradation. Increased AngII at this nephron site stimulates Na reabsorption and increases BP.
Title: Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II.
activity and expression in plasma and lung tissue stays unaffected in lung ischemia-reperfusion injury
Title: Dysregulation of the renin-angiotensin system during lung ischemia-reperfusion injury.
This study demonistrated that PRCP gene is broadly expressed in the brain.
Title: Prolyl carboxypeptidase mRNA expression in the mouse brain.
PRCP regulates cell growth, angiogenesis, and the response to vascular injury
Title: Prolylcarboxypeptidase promotes angiogenesis and vascular repair.
ACE2 metabolizes ANG II in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.
Title: Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry.
PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both standard chow diet and high-fat diet
Title: Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.
analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
Title: The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin levels and increased energy expenditure were also found.
Title: Prolyl carboxypeptidase regulates energy expenditure and the thyroid axis.
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
Title: Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dipeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine-type carboxypeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis involved in wound healing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasma kallikrein-kinin cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood vessel endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of thyroid hormone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lysosomal Pro-X carboxypeptidase

Names: proline carboxypeptidase

NP_082519.1

EC 3.4.16.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028243.3 → NP_082519.1 lysosomal Pro-X carboxypeptidase precursor

See identical proteins and their annotated locations for NP_082519.1

Status: VALIDATED

Source sequence(s)

AC158138, AK051677

Consensus CDS

CCDS21452.1

UniProtKB/Swiss-Prot

Q3TLW3, Q3V302, Q7TMR0, Q8BKK3, Q8R0T8, Q9D049

UniProtKB/TrEMBL

A0A140LHY2

Related

ENSMUSP00000075429.7, ENSMUST00000076052.8

Conserved Domains (2) summary

COG0596
Location:102 → 204

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

cl21494
Location:53 → 472

Abhydrolase; alpha/beta hydrolases