TRK1 Trk1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRK1
Official Full Name: Trk1p
Primary source: SGD:S000003665
Locus tag: YJL129C
See related: AllianceGenome:SGD:S000003665; FungiDB:YJL129C; VEuPathDB:YJL129C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables potassium ion transmembrane transporter activity. Involved in intracellular calcium ion homeostasis and intracellular potassium ion homeostasis. Located in membrane raft. Is active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TRK1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (173599..177306, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dimerisation of the Yeast K[+] Translocation Protein Trk1 Depends on the K[+] Concentration.
Title: Dimerisation of the Yeast K(+) Translocation Protein Trk1 Depends on the K(+) Concentration.
MPM motifs of the yeast SKT protein Trk1 can assemble to form a functional K(+)-translocation system.
Title: MPM motifs of the yeast SKT protein Trk1 can assemble to form a functional K(+)-translocation system.
propose that LHL could modulate Trk1 transport properties via direct influence on a transmembrane helix (M2A) which can switch between bent and straight conformation, thereby directly modifying the radius of the pore and selectivity filter
Title: The S. cerevisiae cation translocation protein Trk1 is functional without its "long hydrophilic loop" but LHL regulates cation translocation activity and selectivity.
Using a combination of physiological, biochemical and proteomic approaches, we show that during growth at suboptimal potassium concentrations, double trk1,2 mutants accumulate less potassium and reach lower yields.
Title: A physiological, biochemical and proteomic characterization of Saccharomyces cerevisiae trk1,2 transport mutants grown under limiting potassium conditions.
Refined structural model of the Saccharomyces cerevisiae Trk1 is presented.
Title: A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues.
Trk1 is not essential for adaptation to potassium changes in Saccharomyces cerevisiae.
Title: Role of Saccharomyces cerevisiae Trk1 in stabilization of intracellular potassium content upon changes in external potassium levels.
Results indicate that, in addition to their role in regulating Trk1 and 2 potassium transporters, Ppz phosphatases 1 and 2 positively affect the residual low affinity potassium transport mechanisms in yeast.
Title: The Ppz protein phosphatases regulate Trk-independent potassium influx in yeast.
the Ppz1-Hal3 interaction is a sensor of intracellular pH that modulates H+ and K+ homeostasis through the regulation of Trk1p activity
Title: pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables high-affinity potassium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular potassium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Trk1p

NP_012406.1

Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

173599..177306 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181562.1 → NP_012406.1 TPA: Trk1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012406.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW56, P12685

UniProtKB/TrEMBL

B5VL49

Conserved Domains (1) summary

TIGR00934
Location:3 → 1173

2a38euk; potassium uptake protein, Trk family