Dynll1 dynein light chain LC8-type 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dynll1provided by MGI
Official Full Name: dynein light chain LC8-type 1provided by MGI
Primary source: MGI:MGI:1861457
See related: Ensembl:ENSMUSG00000009013 AllianceGenome:MGI:1861457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pin; Dlc8; Dnclc1
Summary: Enables dynein intermediate chain binding activity and protein domain specific binding activity. Acts upstream of or within several processes, including cilium organization; mitocytosis; and positive regulation of non-motile cilium assembly. Located in cytoskeleton; cytosol; and membrane. Part of cytoplasmic dynein complex. Is expressed in several structures, including central nervous system; liver; lung; node; and sensory organ. Orthologous to human DYNLL1 (dynein light chain LC8-type 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 89.2), CNS E18 (RPKM 88.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.04 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115435129..115438995, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115297110..115300990, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody Responses and NF-kappaB Pathway Activation.
Title: The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody Responses and NF-κB Pathway Activation.
Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia.
Title: Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia.
Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.
Title: Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.
The authors discovered that the dissociation of the Dynll1-Cox4i1 complex is required for the release of mitochondrial reactive oxygen species and serves as a regulator of intracellular proliferation of Listeria monocytogenes. The study shows that Dynll1 is an inhibitor of mitochondrial reactive oxygen species.
Title: The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species.
oncogenic MYC expression, which is synthetic lethal with Dynll1 deletion in B-2 cells, did not further reduce B-1a cell numbers in Dynll1-defcient mice. we found that the ASCIZ-DYNLL1 axis was also required for the early-juvenile development of aggressive MYC-driven and p53-deficient B cell lymphomas.
Title: Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms.
ASCIZ and its target DYNLL1 are essential for the development and expansion of MYC-driven B cell lymphoma.
Title: The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.
These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.
Title: Arl3 and LC8 regulate dissociation of dynactin from dynein.
a key role for ASCIZ in regulating the survival of developing B cells by activating DYNLL1 expression, which may then modulate Bim-dependent apoptosis
Title: The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.
The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter.
Title: ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.
Our studies suggest an unexpected role for LC8 and provide new mechanistic insights into how SNPH and LC8 together immobilize mitochondria through a dynamic interaction between the docking receptor and axonal cytoskeleton.
Title: Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dynll1 (e-PCR), detects polymorphism
- UniSTS:472905

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables deoxyribonuclease inhibitor activity	ISO Inferred from Sequence Orthology more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in intraciliary retrograde transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intraciliary retrograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA strand resection involved in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA strand resection involved in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cytoplasmic dynein complex	ISA Inferred from Sequence Alignment more info	PubMed
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of dynein complex	IDA Inferred from Direct Assay more info	PubMed
part_of dynein complex	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dynein light chain 1, cytoplasmic

Names: 8 kDa dynein light chain; 8kD LC; 8kDa LC; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; mPIN; protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019682.5 → NP_062656.3 dynein light chain 1, cytoplasmic

See identical proteins and their annotated locations for NP_062656.3

Status: VALIDATED

Source sequence(s)

AC145070

Consensus CDS

CCDS39227.1

UniProtKB/Swiss-Prot

P63168, Q3UGE7

UniProtKB/TrEMBL

Q9D6F6

Related

ENSMUSP00000009157.4, ENSMUST00000009157.4

Conserved Domains (1) summary

cd21452
Location:5 → 88

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family