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    Myorg myogenesis regulating glycosidase (putative) [ Mus musculus (house mouse) ]

    Gene ID: 329828, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myorgprovided by MGI
    Official Full Name
    myogenesis regulating glycosidase (putative)provided by MGI
    Primary source
    MGI:MGI:2140300
    See related
    Ensembl:ENSMUSG00000046312 AllianceGenome:MGI:2140300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm762; NET37; Kiaa1161
    Summary
    Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and skeletal muscle fiber development. Located in endoplasmic reticulum membrane and nuclear membrane. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human MYORG (myogenesis regulating glycosidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 7.2), liver adult (RPKM 7.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myorg in Genome Data Viewer
    Location:
    4 A5; 4 21.69 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41495601..41503132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41491847..41503135, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 24 Neighboring gene STARR-seq mESC enhancer starr_10033 Neighboring gene STARR-positive B cell enhancer ABC_E277 Neighboring gene nudix hydrolase 2 Neighboring gene STARR-seq mESC enhancer starr_10034 Neighboring gene sperm microtubule inner protein 6 Neighboring gene family with sequence similarity 219, member A, opposite strand Neighboring gene family with sequence similarity 219, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification. Yao XP, et al. Neuron, 2018 Jun 27. PMID 29910000
    2. NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation. Datta K, et al. J Biol Chem, 2009 Oct 23. PMID 19706595, Free PMC Article
    3. An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. Ogaki S, et al. BMC Dev Biol, 2011 Mar 1. PMID 21362171, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC175917

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle fiber development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myogenesis-regulating glycosidase
    Names
    full=Nuclear envelope transmembrane protein 37
    nuclear envelope transmembrane protein 37
    NP_001078984.1
    XP_036020082.1
    XP_036020083.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085515.2 → NP_001078984.1  myogenesis-regulating glycosidase

      See identical proteins and their annotated locations for NP_001078984.1

      Status: VALIDATED

      Source sequence(s)
      AL831723, BY246173, BY283520, CO044386
      Consensus CDS
      CCDS38716.1
      UniProtKB/Swiss-Prot
      A2ANN6, B2RU42, Q69ZQ1
      Related
      ENSMUSP00000059038.5, ENSMUST00000054920.5
      Conserved Domains (1) summary
      cd06592
      Location:313 → 684
      GH31_NET37; glucosidase NET37

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41495601..41503132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164190.1 → XP_036020083.1  myogenesis-regulating glycosidase isoform X1

      UniProtKB/Swiss-Prot
      A2ANN6, B2RU42, Q69ZQ1
      Conserved Domains (1) summary
      cd06592
      Location:313 → 684
      GH31_NET37; glucosidase NET37

    2. XM_036164189.1 → XP_036020082.1  myogenesis-regulating glycosidase isoform X1

      UniProtKB/Swiss-Prot
      A2ANN6, B2RU42, Q69ZQ1
      Conserved Domains (1) summary
      cd06592
      Location:313 → 684
      GH31_NET37; glucosidase NET37
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZQ1.2 GenPept UniProtKB/Swiss-Prot:Q69ZQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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