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    Gpr141 G protein-coupled receptor 141 [ Mus musculus (house mouse) ]

    Gene ID: 353346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr141provided by MGI
    Official Full Name
    G protein-coupled receptor 141provided by MGI
    Primary source
    MGI:MGI:2672983
    See related
    Ensembl:ENSMUSG00000053101 AllianceGenome:MGI:2672983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR13
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Orthologous to human GPR141 (G protein-coupled receptor 141). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Gpr141 in Genome Data Viewer
    Location:
    13 A2; 13 7.04 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (19933850..20008499, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (19749680..19824336, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NME/NM23 family member 8 Neighboring gene STARR-positive B cell enhancer mm9_chr13:19879801-19880102 Neighboring gene G protein-coupled receptor 141B Neighboring gene STARR-seq mESC enhancer starr_33802 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33803 Neighboring gene STARR-seq mESC enhancer starr_33804 Neighboring gene STARR-seq mESC enhancer starr_33805 Neighboring gene predicted gene 5446 Neighboring gene STARR-seq mESC enhancer starr_33809 Neighboring gene STARR-positive B cell enhancer ABC_E11780 Neighboring gene STARR-seq mESC enhancer starr_33810 Neighboring gene STARR-positive B cell enhancer ABC_E7207 Neighboring gene STARR-positive B cell enhancer ABC_E4052 Neighboring gene STARR-seq mESC enhancer starr_33811 Neighboring gene engulfment and cell motility 1 Neighboring gene STARR-positive B cell enhancer ABC_E5371 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:20299067-20299268 Neighboring gene STARR-seq mESC enhancer starr_33815 Neighboring gene STARR-seq mESC enhancer starr_33817 Neighboring gene STARR-seq mESC enhancer starr_33818 Neighboring gene predicted gene, 32036

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor. Sawabe A, et al. J Leukoc Biol, 2024 Apr 29. PMID 38226682
    2. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
    3. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor.
      Title: The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxysterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 141
    Names
    G-protein coupled receptor PGR13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181754.4 → NP_861419.3  probable G-protein coupled receptor 141

      See identical proteins and their annotated locations for NP_861419.3

      Status: VALIDATED

      Source sequence(s)
      AC122886, AC153016
      Consensus CDS
      CCDS26264.1
      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Related
      ENSMUSP00000066921.3, ENSMUST00000065335.3
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      19933850..20008499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516705.4 → XP_006516768.1  probable G-protein coupled receptor 141 isoform X1

      See identical proteins and their annotated locations for XP_006516768.1

      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_036158079.1 → XP_036013972.1  probable G-protein coupled receptor 141 isoform X1

      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_006516704.4 → XP_006516767.1  probable G-protein coupled receptor 141 isoform X1

      See identical proteins and their annotated locations for XP_006516767.1

      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_011244316.3 → XP_011242618.1  probable G-protein coupled receptor 141 isoform X1

      See identical proteins and their annotated locations for XP_011242618.1

      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_006516703.4 → XP_006516766.1  probable G-protein coupled receptor 141 isoform X1

      See identical proteins and their annotated locations for XP_006516766.1

      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_011244315.3 → XP_011242617.1  probable G-protein coupled receptor 141 isoform X1

      See identical proteins and their annotated locations for XP_011242617.1

      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. XM_011244313.3 → XP_011242615.1  probable G-protein coupled receptor 141 isoform X1

      See identical proteins and their annotated locations for XP_011242615.1

      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    8. XM_011244314.3 → XP_011242616.1  probable G-protein coupled receptor 141 isoform X1

      See identical proteins and their annotated locations for XP_011242616.1

      UniProtKB/Swiss-Prot
      Q059N8, Q7TQP0, Q80UC5
      UniProtKB/TrEMBL
      Q3U3M0
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQP0.1 GenPept UniProtKB/Swiss-Prot:Q7TQP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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