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    QNS1 glutamine-dependent NAD(+) synthetase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    QNS1
    Official Full Name
    glutamine-dependent NAD(+) synthetase
    Primary source
    SGD:S000001116
    Locus tag
    YHR074W
    See related
    AllianceGenome:SGD:S000001116; FungiDB:YHR074W; VEuPathDB:YHR074W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables NAD+ synthase (glutamine-hydrolyzing) activity and glutaminase activity. Involved in NAD biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See QNS1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (246193..248337)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene snoRNP complex protein NOP10 Neighboring gene oxysterol-binding protein related protein OSH3 Neighboring gene phosphoprotein phosphatase methylesterase 1 Neighboring gene type 2C protein phosphatase PTC7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and properties of yeast nicotinamide adenine dinucleotide synthetase. Yi CK, et al. J Biol Chem, 1972 Aug 10. PMID 4340699
    2. Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. Bieganowski P, et al. J Biol Chem, 2003 Aug 29. PMID 12771147
    3. An ancestral glutamine-dependent NAD(+) synthetase revealed by poor kinetic synergism. Resto M, et al. Biochim Biophys Acta, 2009 Nov. PMID 19647806
    4. Saccharomyces cerevisiae QNS1 codes for NAD(+) synthetase that is functionally conserved in mammals. Suda Y, et al. Yeast, 2003 Aug. PMID 12898714
    5. Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production. Belenky P, et al. PLoS One, 2011 May 11. PMID 21589930, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+ synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamine-dependent NAD(+) synthetase
    NP_011941.1
    • Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      246193..248337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179204.1 → NP_011941.1  TPA: glutamine-dependent NAD(+) synthetase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011941.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL24, P38795
      UniProtKB/TrEMBL
      A6ZSY1, B3LSJ2, B5VK03, C7GWT6, G2WFE7, N1P247
      Conserved Domains (1) summary
      PLN02339
      Location:4 → 704
      PLN02339; NAD+ synthase (glutamine-hydrolysing)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38795.1

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