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    Lrrc18 leucine rich repeat containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 67580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc18provided by MGI
    Official Full Name
    leucine rich repeat containing 18provided by MGI
    Primary source
    MGI:MGI:1914830
    See related
    Ensembl:ENSMUSG00000041673 AllianceGenome:MGI:1914830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTLR1; 4930442L21Rik
    Summary
    Predicted to be located in cytoplasm. Orthologous to human LRRC18 (leucine rich repeat containing 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 144.2) See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc18 in Genome Data Viewer
    Location:
    14 B; 14 19.61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32713339..32737257)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32991382..33015300)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 4 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 36674 Neighboring gene WD repeat and FYVE domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E4104 Neighboring gene STARR-positive B cell enhancer ABC_E1893 Neighboring gene STARR-seq mESC enhancer starr_36348 Neighboring gene predicted gene, 25498 Neighboring gene predicted pseudogene 6340

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel testis-specific gene mtLR1, which is expressed at specific stages of mouse spermatogenesis. Nie DS, et al. Biochem Biophys Res Commun, 2005 Mar 25. PMID 15707978
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 18
    Names
    testis-specific LRR protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146021.1 → NP_001139493.1  leucine-rich repeat-containing protein 18 isoform 2

      See identical proteins and their annotated locations for NP_001139493.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) lacks N-terminal sequence when it is compared to isoform 1.
      Source sequence(s)
      AK005666, AK006063, AK015365, BB017856, BC048444
      Consensus CDS
      CCDS49440.1
      UniProtKB/TrEMBL
      D3Z3F9
      Related
      ENSMUSP00000113608.2, ENSMUST00000120866.8
      Conserved Domains (2) summary
      PLN00113
      Location:49 → 200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:30 → 51
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_026253.4 → NP_080529.1  leucine-rich repeat-containing protein 18 isoform 1

      See identical proteins and their annotated locations for NP_080529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC165262, AK014952, AK015365
      Consensus CDS
      CCDS26924.1
      UniProtKB/Swiss-Prot
      Q6P8T8, Q80ZT3, Q9CQ07, Q9CW01, Q9DA89
      UniProtKB/TrEMBL
      D3Z3F9
      Related
      ENSMUSP00000041199.5, ENSMUST00000038956.12
      Conserved Domains (2) summary
      PLN00113
      Location:49 → 200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:30 → 51
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      32713339..32737257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519457.4 → XP_006519520.1  leucine-rich repeat-containing protein 18 isoform X1

      See identical proteins and their annotated locations for XP_006519520.1

      UniProtKB/Swiss-Prot
      Q6P8T8, Q80ZT3, Q9CQ07, Q9CW01, Q9DA89
      UniProtKB/TrEMBL
      D3Z3F9
      Conserved Domains (2) summary
      PLN00113
      Location:49 → 200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:30 → 51
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_006519458.4 → XP_006519521.1  leucine-rich repeat-containing protein 18 isoform X1

      See identical proteins and their annotated locations for XP_006519521.1

      UniProtKB/Swiss-Prot
      Q6P8T8, Q80ZT3, Q9CQ07, Q9CW01, Q9DA89
      UniProtKB/TrEMBL
      D3Z3F9
      Conserved Domains (2) summary
      PLN00113
      Location:49 → 200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:30 → 51
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ07.1 GenPept UniProtKB/Swiss-Prot:Q9CQ07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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