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    AGP2 Agp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AGP2
    Official Full Name
    Agp2p
    Primary source
    SGD:S000000336
    Locus tag
    YBR132C
    See related
    AllianceGenome:SGD:S000000336; FungiDB:YBR132C; VEuPathDB:YBR132C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Involved in positive regulation of (R)-carnitine transmembrane transport and positive regulation of polyamine transmembrane transport. Located in endoplasmic reticulum membrane; fungal-type vacuole membrane; and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AGP2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (499652..501442, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene She3p Neighboring gene Ccz1p Neighboring gene protein arginine N-methyltransferase Neighboring gene cyclin-dependent protein kinase regulatory subunit CKS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of OsPUT1, a rice polyamine uptake transporter. Mulangi V, et al. Planta, 2012 Jan. PMID 21796369
    2. Putative ancient microorganisms from amber nuggets. Veiga-Crespo P, et al. Int Microbiol, 2007 Jun. PMID 17661290
    3. Carnitine uptake by AGP2 in yeast Saccharomyces cerevisiae is dependent on Hog1 MAP kinase pathway. Lee J, et al. Mol Cells, 2002 Jun 30. PMID 12132580
    4. A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a mechanism of resistance to the anticancer drug bleomycin. Aouida M, et al. Cancer Res, 2004 Feb 1. PMID 14871844
    5. Disruption of AtOCT1, an organic cation transporter gene, affects root development and carnitine-related responses in Arabidopsis. Lelandais-Brière C, et al. Plant J, 2007 Jul. PMID 17521409

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Agp2 might respond to environmental cues and thus regulate the expression of several genes including those involved in polyamine transport.
      Title: Agp2, a member of the yeast amino acid permease family, positively regulates polyamine transport at the transcriptional level.
    2. AGP2 encodes the first eukaryotic permease that preferentially uses spermidine over putrescine as a high affinity substrate and plays a central role in the uptake of polyamines in yeast
      Title: AGP2 encodes the major permease for high affinity polyamine import in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of (R)-carnitine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of polyamine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Agp2p
    NP_009690.1
    • Plasma membrane regulator of high affinity polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes; null mutant is cycloheximide (CHX) resistant; ubiquitinated Agp2p is rapidly degraded in a Brp1p-dependent manner in the presence of CHX; localizes to the plasma membrane, the vacuolar membrane and the ER membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      499652..501442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178480.1 → NP_009690.1  TPA: Agp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009690.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQC9, P38090
      UniProtKB/TrEMBL
      B5VE93, G2W9D6
      Conserved Domains (1) summary
      COG0833
      Location:41 → 596
      LysP; Amino acid permease [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38090.1

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