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    CLB1 B-type cyclin CLB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CLB1
    Official Full Name
    B-type cyclin CLB1
    Primary source
    SGD:S000003340
    Locus tag
    YGR108W
    See related
    AllianceGenome:SGD:S000003340; FungiDB:YGR108W; VEuPathDB:YGR108W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SCB1
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including cell cycle G2/M phase transition; mitotic spindle organization; and regulation of cell cycle process. Located in cytoplasm and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1) and CCNB2 (cyclin B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CLB1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (703636..705051)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene tRNA-Lys Neighboring gene B-type cyclin CLB6 Neighboring gene tRNA-Cys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclin B-cdk activity stimulates meiotic rereplication in budding yeast. Strich R, et al. Genetics, 2004 Aug. PMID 15342503, Free PMC Article
    2. Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae. Kelliher CM, et al. Mol Biol Cell, 2018 Nov 1. PMID 30207828, Free PMC Article
    3. Cdc28 and Ime2 possess redundant functions in promoting entry into premeiotic DNA replication in Saccharomyces cerevisiae. Guttmann-Raviv N, et al. Genetics, 2001 Dec. PMID 11779796, Free PMC Article
    4. A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Ghiara JB, et al. Cell, 1991 Apr 5. PMID 1849458
    5. Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation. Rahal R, et al. Genes Dev, 2008 Jun 1. PMID 18519644, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that meiosis-specific phosphorylation of B-cyclin Clb1 requires its import to the nucleus.
      Title: CDK-dependent nuclear localization of B-cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast.
    2. inactivation of the negative regulatory system by deletion of the HIR1 gene relieved the dependence of HTA1-HTB1 transcription on the mitotic Clb1/Cb2 cyclins
      Title: The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.
    3. Deletion of CLB1 or CLB3 allows cdc14-arrested cells to complete cytokinesis
      Title: Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.
    4. results show that the FEAR network acts in part by stimulating phosphorylation of Net1 by Clb-Cdk, which directly weakens the interaction of Cdc14 with Net1, allowing for Cdc14 activation and mitotic exit
      Title: Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G2/MI transition of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic spindle pole body separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of meiosis I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of meiosis I IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B-type cyclin CLB1
    NP_011622.1
    • B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      703636..705051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181237.1 → NP_011622.1  TPA: B-type cyclin CLB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUN9, P24868
      UniProtKB/TrEMBL
      A6ZUC3, B3LIB9, B5VJ53, C8Z900, N1P5V6
      Conserved Domains (1) summary
      COG5024
      Location:1 → 467
      COG5024; Cyclin [Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24868.1

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