Myoz1 myozenin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myoz1provided by MGI
Official Full Name: myozenin 1provided by MGI
Primary source: MGI:MGI:1929471
See related: Ensembl:ENSMUSG00000068697 AllianceGenome:MGI:1929471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FATZ; Myoz; 2310001N11Rik
Summary: Enables protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including negative regulation of calcineurin-NFAT signaling cascade; negative regulation of skeletal muscle tissue regeneration; and sarcomere organization. Acts upstream of or within with a positive effect on skeletal muscle fiber adaptation. Located in actin cytoskeleton. Is expressed in diaphragm; heart; musculature; and tongue. Orthologous to human MYOZ1 (myozenin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 65.7) and lung adult (RPKM 3.9) See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.53 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (20699170..20706608, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (20649102..20656540, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results provide insights into the potential functions of miR-432 as well as its proposed target, MYOZ1, during muscle development.
Title: Targeting of miR-432 to myozenin1 to regulate myoblast proliferation and differentiation.
Calsarcin-2 skeletal muscle specific protein deficiency increases execrcise capacity in mice through calcineurin/NFAT activation.
Title: Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation.
study defined proximal promoter region of calsarcin-1 (CS-1)& calsarcin-2 (CS-2)genes; data suggest NF-kappaB is required for transcription of CS-1 gene, but not CS-2
Title: NF-kappaB mediates the transcription of mouse calsarcin-1 gene, but not calsarcin-2, in C2C12 cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV090278 (e-PCR)
- UniSTS:165896

Myoz1 (e-PCR), detects polymorphism
- UniSTS:508568

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FATZ binding	IBA Inferred from Biological aspect of Ancestor more info
enables FATZ binding	IEA Inferred from Electronic Annotation more info
enables FATZ binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actinin binding	IEA Inferred from Electronic Annotation more info
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables telethonin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect skeletal muscle fiber adaptation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IEA Inferred from Electronic Annotation more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pseudopodium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myozenin-1

Names: calcineurin-2; calsarcin-2; filamin-, actinin- and telethonin-binding protein; skeletal muscle-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.