Bicdl1 BICD family like cargo adaptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bicdl1provided by MGI
Official Full Name: BICD family like cargo adaptor 1provided by MGI
Primary source: MGI:MGI:1922915
See related: Ensembl:ENSMUSG00000041609 AllianceGenome:MGI:1922915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccdc64; BICDR-1; 2210403N09Rik
Summary: Enables dynactin binding activity and small GTPase binding activity. Involved in Golgi to secretory granule transport and neuron projection development. Located in centrosome. Is expressed in several structures, including adrenal gland; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human BICDL1 (BICD family like cargo adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 26.8), CNS E18 (RPKM 20.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.1 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115786233..115869824, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115648174..115731844, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BICDR-1 has an important role as temporal regulator of secretory trafficking during the early phase of neuronal differentiation
Title: Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynactin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to secretory granule transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to secretory granule transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BICD family-like cargo adapter 1

Names: BICD-related protein 1; bicaudal D-related protein 1; coiled-coil domain containing 64; coiled-coil domain-containing protein 64A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080808.2 → NP_001074277.1 BICD family-like cargo adapter 1

See identical proteins and their annotated locations for NP_001074277.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AC139562, GU973876

Consensus CDS

CCDS39230.1

UniProtKB/Swiss-Prot

A0JNT9, Q8C9J5, Q8CB56, Q8R1D2

UniProtKB/TrEMBL

D4PEG0

Related

ENSMUSP00000053547.7, ENSMUST00000055408.13

Conserved Domains (1) summary

TIGR02168
Location:101 → 331

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

NR_151598.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC139562, AC159539
NR_151599.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC139562, AC159539
NR_151600.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' end and contains and alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC159539
NR_151601.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' end and contains and alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC159539
NR_151602.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC159539
NR_151603.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC159539

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

115786233..115869824 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530487.4 → XP_006530550.1 BICD family-like cargo adapter 1 isoform X2

UniProtKB/TrEMBL

D4PEG0

Conserved Domains (1) summary

TIGR02168
Location:101 → 331

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006530489.4 → XP_006530552.1 BICD family-like cargo adapter 1 isoform X3

UniProtKB/TrEMBL

D4PEG0

Conserved Domains (1) summary

TIGR02168
Location:101 → 335

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006530490.5 → XP_006530553.1 BICD family-like cargo adapter 1 isoform X1

UniProtKB/TrEMBL

D4PEG0

Conserved Domains (1) summary

TIGR02168
Location:101 → 335

SMC_prok_B; chromosome segregation protein SMC, common bacterial type