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    MSL1 U2 snRNP complex subunit MSL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSL1
    Official Full Name
    U2 snRNP complex subunit MSL1
    Primary source
    SGD:S000001448
    Locus tag
    YIR009W
    See related
    AllianceGenome:SGD:S000001448; FungiDB:YIR009W; VEuPathDB:YIR009W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YIB9
    Summary
    Enables U2 snRNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U2-type prespliceosome. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA (small nuclear ribonucleoprotein polypeptide A) and SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSL1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (374525..374860)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene hydrolase Neighboring gene DNA primase subunit PRI1 Neighboring gene MIND complex subunit DSN1 Neighboring gene Sts1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B" protein. Tang J, et al. Mol Cell Biol, 1996 Jun. PMID 8649387, Free PMC Article
    2. Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B' that are encoded separately in human, potato, and yeast. Polycarpou-Schwarz M, et al. RNA, 1996 Jan. PMID 8846293, Free PMC Article
    3. Involvement of Nst1p/YNL091w and Msl1p, a U2B'' splicing factor, in Saccharomyces cerevisiae salt tolerance. Goossens A, et al. Yeast, 2002 Feb. PMID 11816027
    4. The yeast U2A'/U2B complex is required for pre-spliceosome formation. Caspary F, et al. EMBO J, 1998 Nov 2. PMID 9799242, Free PMC Article
    5. Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly. Caspary F, et al. EMBO J, 1999 Jun 15. PMID 10369685, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U2 snRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP complex subunit MSL1
    NP_012274.1
    • U2B component of U2 snRNP; involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      374525..374860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179531.1 → NP_012274.1  TPA: U2 snRNP complex subunit MSL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVT9, P40567
      UniProtKB/TrEMBL
      A6ZVS8, B3LTK0, C7GJG3, C8ZAQ8, G2WGF5, N1P1S1
      Conserved Domains (1) summary
      cd12246
      Location:29 → 105
      RRM1_U1A_like; RNA recognition motif 1 (RRM1) found in the U1A/U2B"/SNF protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40567.1

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