Rnh1 ribonuclease/angiogenin inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnh1provided by RGD
Official Full Name: ribonuclease/angiogenin inhibitor 1provided by RGD
Primary source: RGD:621398
See related: EnsemblRapid:ENSRNOG00000016416 AllianceGenome:RGD:621398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rnh
Summary: Predicted to enable ribonuclease inhibitor activity. Predicted to be involved in cell migration; regulation of Arp2/3 complex-mediated actin nucleation; and regulation of angiogenesis. Predicted to be located in cytosol. Predicted to be part of angiogenin-PRI complex. Predicted to be active in several cellular components, including lamellipodium; nucleoplasm; and plasma membrane. Orthologous to human RNH1 (ribonuclease/angiogenin inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 309.8), Kidney (RPKM 276.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205698882..205711348, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196269293..196281763, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214151341..214163807, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNH1 protein is upregulated after spinal cord injury.
Title: Identification and distribution of rRNH1, a gene upregulated after spinal cord primary neuron injury.
Rnh1-mediated RhoA inactivation enhances the differentiation and myelination in oligodendrocytes.
Title: Rnh1 promotes differentiation and myelination via RhoA in oligodendrocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

BI274477 (e-PCR)
- UniSTS:249094

D1Bda73 (e-PCR)
- UniSTS:239824

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ribonuclease inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ribonuclease inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ribonuclease inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in tRNA stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of angiogenin-PRI complex	IBA Inferred from Biological aspect of Ancestor more info
part_of angiogenin-PRI complex	IEA Inferred from Electronic Annotation more info
part_of angiogenin-PRI complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribonuclease inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270762.1 → NP_001257691.1 ribonuclease inhibitor isoform a

See identical proteins and their annotated locations for NP_001257691.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

BC070501, JAXUCZ010000001

UniProtKB/Swiss-Prot

P29315, Q6IRS9

UniProtKB/TrEMBL

A6HXQ3

Related

ENSRNOP00000022241.3, ENSRNOT00000022241.7

Conserved Domains (3) summary

COG4886
Location:46 → 361

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:37 → 356

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001270763.1 → NP_001257692.1 ribonuclease inhibitor isoform b

See identical proteins and their annotated locations for NP_001257692.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

BC070501, JAXUCZ010000001

UniProtKB/Swiss-Prot

P29315, Q6IRS9

UniProtKB/TrEMBL

E2RUH2, F7F8M8

Conserved Domains (3) summary

cd00116
Location:1 → 320

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:2 → 24

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:282 → 429

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_139105.3 → NP_620805.2 ribonuclease inhibitor isoform b

See identical proteins and their annotated locations for NP_620805.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

BC070501, JAXUCZ010000001

UniProtKB/Swiss-Prot

P29315, Q6IRS9

UniProtKB/TrEMBL

E2RUH2, F7F8M8

Related

ENSRNOP00000098900.1, ENSRNOT00000154403.1

Conserved Domains (3) summary

cd00116
Location:1 → 320

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:2 → 24

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:282 → 429

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

205698882..205711348 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101716.2 → XP_038957644.1 ribonuclease inhibitor isoform X1

UniProtKB/Swiss-Prot

P29315, Q6IRS9

UniProtKB/TrEMBL

E2RUH2, F7F8M8

Conserved Domains (3) summary

cd00116
Location:1 → 320

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:2 → 24

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:282 → 429

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...