Reep6 receptor accessory protein 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Reep6provided by RGD
Official Full Name: receptor accessory protein 6provided by RGD
Primary source: RGD:1309508
See related: EnsemblRapid:ENSRNOG00000033262 AllianceGenome:RGD:1309508
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dp1l1
Summary: Predicted to be involved in detection of light stimulus involved in visual perception and regulation of intracellular transport. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; photoreceptor inner segment; and rod spherule. Human ortholog(s) of this gene implicated in retinitis pigmentosa 77. Orthologous to human REEP6 (receptor accessory protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 206.5), Liver (RPKM 54.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10024601..10031507, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9373927..9380845, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12240059..12246814, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-672-5p-Mediated Upregulation of REEP6 in Spinal Dorsal Horn Participates in Bortezomib-Induced Neuropathic Pain in Rats.
Title: MiR-672-5p-Mediated Upregulation of REEP6 in Spinal Dorsal Horn Participates in Bortezomib-Induced Neuropathic Pain in Rats.
TB2-like 1 is a membrane protein that belongs to the YOP1/TB2/DP1/HVA22 family, and it probably plays an important role in intracellular membrane trafficking in RGCs
Title: Deleted in polyposis 1-like 1 gene (Dp1l1): a novel gene richly expressed in retinal ganglion cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129194 (e-PCR)
- UniSTS:212502

RH129166 (e-PCR)
- UniSTS:212474

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
involved_in detection of light stimulus involved in visual perception	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in rod spherule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor expression-enhancing protein 6

Names: deleted in polyposis 1-like 1; polyposis locus protein 1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013218.1 → NP_001013236.1 receptor expression-enhancing protein 6

See identical proteins and their annotated locations for NP_001013236.1

Status: PROVISIONAL

Source sequence(s)

BC083830

UniProtKB/Swiss-Prot

Q5XI60

UniProtKB/TrEMBL

A6K8M4

Conserved Domains (1) summary

pfam03134
Location:66 → 143

TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10024601..10031507 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240967.5 → XP_006241029.2 receptor expression-enhancing protein 6 isoform X1

UniProtKB/TrEMBL

A0A8I6AGE9, A6K8M3

Related

ENSRNOP00000091886.1, ENSRNOT00000104094.2

Conserved Domains (1) summary

pfam03134
Location:66 → 143

TB2_DP1_HVA22; TB2/DP1, HVA22 family