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    Tmem131l transmembrane 131 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679811, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem131lprovided by RGD
    Official Full Name
    transmembrane 131 likeprovided by RGD
    Primary source
    RGD:1583677
    See related
    EnsemblRapid:ENSRNOG00000009837 AllianceGenome:RGD:1583677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305449
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human TMEM131L (transmembrane 131 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 231.7), Spleen (RPKM 217.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem131l in Genome Data Viewer
    Location:
    2q34
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (171555673..171689774, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (169257659..169391773, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (182897332..183031273, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 2 Neighboring gene uncharacterized LOC134485932 Neighboring gene uncharacterized LOC134485933 Neighboring gene peflin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. Maharzi N, et al. J Immunol, 2013 Jun 15. PMID 23690469
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 131-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399524.1 → NP_001386453.1  transmembrane protein 131-like isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZRG1
      Related
      ENSRNOP00000013260.6, ENSRNOT00000013260.9
      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    2. NM_001399525.1 → NP_001386454.1  transmembrane protein 131-like isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      171555673..171689774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282520.1 → XP_063138590.1  transmembrane protein 131-like isoform X5

    2. XM_006232547.4 → XP_006232609.1  transmembrane protein 131-like isoform X1

      See identical proteins and their annotated locations for XP_006232609.1

      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    3. XM_008761116.4 → XP_008759338.1  transmembrane protein 131-like isoform X4

      See identical proteins and their annotated locations for XP_008759338.1

      UniProtKB/TrEMBL
      A0A8I6AV47
      Related
      ENSRNOP00000097919.1, ENSRNOT00000115508.2
      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    4. XM_039103734.2 → XP_038959662.1  transmembrane protein 131-like isoform X2

      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    5. XM_063282521.1 → XP_063138591.1  transmembrane protein 131-like isoform X7

    6. XM_006232549.5 → XP_006232611.1  transmembrane protein 131-like isoform X3

      See identical proteins and their annotated locations for XP_006232611.1

      Conserved Domains (1) summary
      cl13764
      Location:55 → 138
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    7. XM_006232550.4 → XP_006232612.1  transmembrane protein 131-like isoform X6

      See identical proteins and their annotated locations for XP_006232612.1

      Conserved Domains (1) summary
      cl13764
      Location:20 → 103
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    RNA

    1. XR_005501038.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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