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    Gpr75 G protein-coupled receptor 75 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498434, updated on 2-Nov-2024

    Summary

    Official Symbol
    Gpr75provided by RGD
    Official Full Name
    G protein-coupled receptor 75provided by RGD
    Primary source
    RGD:1566385
    See related
    EnsemblRapid:ENSRNOG00000022176 AllianceGenome:RGD:1566385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable C-C chemokine receptor activity. Predicted to be involved in chemokine-mediated signaling pathway. Predicted to be active in plasma membrane. Orthologous to human GPR75 (G protein-coupled receptor 75). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 31.8), Lung (RPKM 8.2) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gpr75 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (108810462..108821926)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (104609542..104618885)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (115270452..115278510)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene macrophage migration inhibitory factor, pseudogene 1 Neighboring gene proteasome activator subunit 4 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    probable G-protein coupled receptor 75
    Names
    G protein-coupled receptor GPR75

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109096.1NP_001102566.1  probable G-protein coupled receptor 75

      See identical proteins and their annotated locations for NP_001102566.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473996
      UniProtKB/TrEMBL
      A6JQD2, D3Z826
      Related
      ENSRNOP00000029471.4, ENSRNOT00000033437.6
      Conserved Domains (1) summary
      pfam00001
      Location:59237
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      108810462..108821926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251616.5XP_006251678.1  probable G-protein coupled receptor 75 isoform X1

      See identical proteins and their annotated locations for XP_006251678.1

      UniProtKB/TrEMBL
      A6JQD2, D3Z826
      Conserved Domains (1) summary
      pfam00001
      Location:59237
      7tm_1; 7 transmembrane receptor (rhodopsin family)