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    RFC3 replication factor C subunit 3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RFC3
    Official Full Name
    replication factor C subunit 3
    Primary source
    SGD:S000005234
    Locus tag
    YNL290W
    See related
    AllianceGenome:SGD:S000005234; FungiDB:YNL290W; VEuPathDB:YNL290W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP hydrolysis activity. Contributes to DNA clamp loader activity. Involved in leading strand elongation. Located in cytosol and nucleus. Part of chromosome. Orthologous to human RFC5 (replication factor C subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RFC3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (86218..87240)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS4 Neighboring gene Mid1p Neighboring gene Pcl1p Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of the Saccharomyces cerevisiae RFC3 gene, an essential component of replication factor C. Li X, et al. Proc Natl Acad Sci U S A, 1994 Feb 1. PMID 8302859, Free PMC Article
    2. The Schizosaccharomyces pombe rfc3+ gene encodes a homologue of the human hRFC36 and Saccharomyces cerevisiae Rfc3 subunits of replication factor C. Gray FC, et al. Curr Genet, 2000 Mar. PMID 10794172
    3. Cloning and characterization of the essential Saccharomyces cerevisiae RFC4 gene encoding the 37-kDa subunit of replication factor C. Li X, et al. J Biol Chem, 1994 Aug 26. PMID 8063832
    4. Dominant mutations in three different subunits of replication factor C suppress replication defects in yeast PCNA mutants. Amin NS, et al. Genetics, 1999 Dec. PMID 10581271, Free PMC Article
    5. Eukaryotic DNA mismatch repair. Kolodner RD, et al. Curr Opin Genet Dev, 1999 Feb. PMID 10072354

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA clamp unloading IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mismatch repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ctf18 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Elg1 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Elg1 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Elg1 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of Rad17 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rad17 RFC-like complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rad17 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 3
    NP_014109.1
    • Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      86218..87240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183128.1 → NP_014109.1  TPA: replication factor C subunit 3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q3, P38629
      UniProtKB/TrEMBL
      A6ZSI8, B3LPC8, C7GS53, C8ZGN1, G2WLH7, N1NXW7
      Conserved Domains (1) summary
      PRK00440
      Location:11 → 324
      rfc; replication factor C small subunit; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38629.1

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