PRY1 sterol-binding protein [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PRY1
Official Full Name: sterol-binding protein
Primary source: SGD:S000003615
Locus tag: YJL079C
See related: AllianceGenome:SGD:S000003615; FungiDB:YJL079C; VEuPathDB:YJL079C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cholesterol binding activity; fatty acid binding activity; and magnesium ion binding activity. Involved in fatty acid transport and sterol transport. Located in extracellular region. Orthologous to several human genes including GLIPR2 (GLI pathogenesis related 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cholesterol binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables sterol binding	IDA Inferred from Direct Assay more info	PubMed
enables sterol binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in sterol transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sterol transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole	HDA more info	PubMed
located_in nuclear envelope	HDA more info	PubMed

NP_012456.1

Lipid binding protein; binds to both free fatty acids with preference for saturated long-chain fatty acids and to sterols; contains two independent lipid-binding sites; involved in the export of free fatty acids and acetylated sterols; export functions are redundant with PRY2, and PRY3; important for survival of cells that accumulate free fatty acids; involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP/SCP protein superfamily

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The following sections contain reference sequences that belong to a specific genome build. Explain