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    GRH1 Grh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852129, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GRH1
    Official Full Name
    Grh1p
    Primary source
    SGD:S000002925
    Locus tag
    YDR517W
    See related
    AllianceGenome:SGD:S000002925; FungiDB:YDR517W; VEuPathDB:YDR517W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular response to starvation; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein secretion. Located in Golgi membrane and cis-Golgi network. Orthologous to several human genes including GORASP2 (golgi reassembly stacking protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GRH1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1477239..1478357)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Slf1p Neighboring gene putative glucokinase Neighboring gene protein disulfide isomerase EUG1 Neighboring gene peptidylprolyl isomerase family protein FPR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast GRASP Grh1 displays a high polypeptide backbone mobility along with an amyloidogenic behavior. Fontana NA, et al. Sci Rep, 2018 Oct 24. PMID 30356074, Free PMC Article
    2. The yeast GRASP Grh1 colocalizes with COPII and is dispensable for organizing the secretory pathway. Levi SK, et al. Traffic, 2010 Sep. PMID 20573068, Free PMC Article
    3. Genetic selection of peptide inhibitors of biological pathways. Norman TC, et al. Science, 1999 Jul 23. PMID 10417390
    4. Golgi membrane-associated degradation pathway in yeast and mammals. Yamaguchi H, et al. EMBO J, 2016 Sep 15. PMID 27511903, Free PMC Article
    5. Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion. Bruns C, et al. J Cell Biol, 2011 Dec 12. PMID 22144692, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Grh1-Bug1 complex contributes to a redundant network of interactions that mediates consumption of COPII vesicles and formation of the cis-Golgi
      Title: The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Grh1p
    NP_010805.1
    • Acetylated cis-Golgi protein, homolog of human GRASP65; required for unconventional protein secretion (UPS) of Acb1p in response to starvation; forms amyloid-like fibrils under heat shock, and coacervates through liquid-liquid phase separation during starvation, as a precursor to compartment for unconventional protein secretion (CUPS) biogenesis; forms a complex with the coiled-coil protein Bug1p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1477239..1478357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180825.1 → NP_010805.1  TPA: Grh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010805.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTD8, Q04410
      UniProtKB/TrEMBL
      B3LFF3, C7GKV0, C8Z673, N1P7Q5
      Conserved Domains (1) summary
      COG5233
      Location:1 → 372
      GRH1; Peripheral Golgi membrane protein [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04410.1

    Gene LinkOut

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