TFA2 transcription factor TFIIE subunit TFA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TFA2
Official Full Name: transcription factor TFIIE subunit TFA2
Primary source: SGD:S000001770
Locus tag: YKR062W
See related: AllianceGenome:SGD:S000001770; FungiDB:YKR062W; VEuPathDB:YKR062W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase II complex binding activity; TFIIH-class transcription factor complex binding activity; and single-stranded DNA binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIE complex and transcription preinitiation complex. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to TFIIH-class transcription factor complex binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to TFIIH-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIE complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIE complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIE complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription preinitiation complex	IDA Inferred from Direct Assay more info	PubMed

NP_012988.1

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