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    HTD2 hydroxyacyl-thioester dehydratase HTD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856464, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HTD2
    Official Full Name
    hydroxyacyl-thioester dehydratase HTD2
    Primary source
    SGD:S000001109
    Locus tag
    YHR067W
    See related
    AllianceGenome:SGD:S000001109; FungiDB:YHR067W; VEuPathDB:YHR067W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RMD12
    Summary
    Enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HTD2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (230970..231812)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene RNA-dependent ATPase RRP3 Neighboring gene rRNA-binding ribosome biosynthesis protein Neighboring gene deoxyhypusine synthase Neighboring gene exosome non-catalytic core subunit RRP4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology. Kastaniotis AJ, et al. Mol Microbiol, 2004 Sep. PMID 15387819
    2. Identification of the Leishmania major proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as components of fatty acid synthase II. Gurvitz A. J Biomed Biotechnol, 2009. PMID 20145708, Free PMC Article
    3. Identification of a novel mycobacterial 3-hydroxyacyl-thioester dehydratase, HtdZ (Rv0130), by functional complementation in yeast. Gurvitz A, et al. J Bacteriol, 2008 Jun. PMID 18375556, Free PMC Article
    4. An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing. Autio KJ, et al. FASEB J, 2008 Feb. PMID 17898086
    5. Genetic dissection of the mitochondrial lipoylation pathway in yeast. Pietikäinen LP, et al. BMC Biol, 2021 Jan 25. PMID 33487163, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest a crucial role of YHR067w in maintenance of mitochondrial respiratory competence and morphology in yeast.
      Title: Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacyl-thioester dehydratase HTD2
    NP_011934.1
    • Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      230970..231812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179197.1 → NP_011934.1  TPA: hydroxyacyl-thioester dehydratase HTD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL16, P38790
      UniProtKB/TrEMBL
      A6ZSX3, B3LSI5, B5VJZ5, C7GWS8, C8Z9K5, N1P9D5
      Conserved Domains (1) summary
      COG3777
      Location:4 → 280
      HTD2; Hydroxyacyl-ACP dehydratase HTD2, hotdog domain [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38790.1

    Gene LinkOut

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