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    Rgs7bp regulator of G-protein signalling 7 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 52882, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rgs7bpprovided by MGI
    Official Full Name
    regulator of G-protein signalling 7 binding proteinprovided by MGI
    Primary source
    MGI:MGI:106334
    See related
    Ensembl:ENSMUSG00000021719 AllianceGenome:MGI:106334
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R7bp; D13Bwg1146e; A930030I01Rik
    Summary
    Involved in regulation of postsynaptic membrane potential. Acts upstream of or within G protein-coupled receptor signaling pathway. Located in cytoplasm; nucleus; and plasma membrane. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Is expressed in trigeminal ganglion. Orthologous to human RGS7BP (regulator of G protein signaling 7 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 23.0), cortex adult (RPKM 22.2) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Rgs7bp in Genome Data Viewer
    Location:
    13 D1; 13 56.9 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (105082412..105191438, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104945904..105054930, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene shisa like 2B Neighboring gene STARR-seq mESC enhancer starr_35543 Neighboring gene STARR-seq mESC enhancer starr_35545 Neighboring gene STARR-positive B cell enhancer ABC_E11556 Neighboring gene predicted gene, 41048 Neighboring gene H3 histone, family 3 pseudogene Neighboring gene 5' nucleotidase, ecto-like Neighboring gene STARR-positive B cell enhancer ABC_E7275 Neighboring gene ring finger protein 180 Neighboring gene predicted gene, 25631

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of G-protein signaling 7-binding protein
    Names
    R7 binding protein
    R7 family-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029879.2NP_084155.2  regulator of G-protein signaling 7-binding protein

      See identical proteins and their annotated locations for NP_084155.2

      Status: VALIDATED

      Source sequence(s)
      AC154297, AK046733, BY726818
      Consensus CDS
      CCDS36774.1
      UniProtKB/Swiss-Prot
      Q0VF69, Q3UVC4, Q8BQP9, Q8CBD6, Q9CTP1
      Related
      ENSMUSP00000066614.6, ENSMUST00000063551.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      105082412..105191438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517722.4XP_006517785.1  regulator of G-protein signaling 7-binding protein isoform X1