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    Scyl3 SCY1-like 3 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 240880, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Scyl3provided by MGI
    Official Full Name
    SCY1-like 3 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1921385
    See related
    Ensembl:ENSMUSG00000026584 AllianceGenome:MGI:1921385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pace1; 6030457O16; 1200016D23Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within inflammatory response; neuron differentiation; and protein localization. Located in Golgi membrane. Is expressed in retina inner nuclear layer and retina outer nuclear layer. Orthologous to human SCYL3 (SCY1 like pseudokinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 4.3), CNS E11.5 (RPKM 4.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scyl3 in Genome Data Viewer
    Location:
    1 H2.1- H2.2; 1 71.23 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163756669..163782695)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163929100..163955126)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02857 Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:165709472-165709665 Neighboring gene STARR-seq mESC enhancer starr_02858 Neighboring gene predicted gene, 51663 Neighboring gene kinesin-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_02859 Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene STARR-positive B cell enhancer ABC_E2015 Neighboring gene STARR-seq mESC enhancer starr_02860 Neighboring gene methyltransferase like 18 Neighboring gene selectin, endothelial cell

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. Kuliyev E, et al. J Neurosci, 2018 Mar 7. PMID 29437892, Free PMC Article
    2. Variegated gene expression caused by cell-specific long-range DNA interactions. Noordermeer D, et al. Nat Cell Biol, 2011 Jun 26. PMID 21706023, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within spinal cord motor neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-associating with the carboxyl-terminal domain of ezrin
    Names
    SCY1-like protein 3
    ezrin-binding partner PACE-1
    ezrin-binding protein PACE-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286002.1 → NP_001272931.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AK162937, BC043085, BC066800
      Consensus CDS
      CCDS69967.1
      UniProtKB/Swiss-Prot
      Q9DBQ7
      Related
      ENSMUSP00000125735.2, ENSMUST00000161908.8
      Conserved Domains (3) summary
      pfam00069
      Location:26 → 245
      Pkinase; Protein kinase domain
      sd00044
      Location:256 → 283
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:9 → 247
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001286003.1 → NP_001272932.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 3

      See identical proteins and their annotated locations for NP_001272932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' structure and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AK044100, BB653492, BC043085
      UniProtKB/Swiss-Prot
      Q9DBQ7
      Conserved Domains (1) summary
      sd00044
      Location:28 → 55
      HEAT; HEAT repeat [structural motif]

    3. NM_001357426.1 → NP_001344355.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' structure and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AC158964
      Conserved Domains (1) summary
      sd00044
      Location:28 → 55
      HEAT; HEAT repeat [structural motif]

    4. NM_028776.5 → NP_083052.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 1

      See identical proteins and their annotated locations for NP_083052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BB653492, BC043085, BC066800
      Consensus CDS
      CCDS15430.1
      UniProtKB/Swiss-Prot
      Q3TRA7, Q6NY01, Q8BQC9, Q8BRJ1, Q9DBQ7
      Related
      ENSMUSP00000027876.5, ENSMUST00000027876.11
      Conserved Domains (3) summary
      pfam00069
      Location:26 → 245
      Pkinase; Protein kinase domain
      sd00044
      Location:256 → 283
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:9 → 247
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      163756669..163782695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496849.2 → XP_006496912.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X6

      See identical proteins and their annotated locations for XP_006496912.1

      UniProtKB/Swiss-Prot
      Q9DBQ7
      Conserved Domains (1) summary
      sd00044
      Location:28 → 55
      HEAT; HEAT repeat [structural motif]

    2. XM_006496845.3 → XP_006496908.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:9 → 246
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006496846.4 → XP_006496909.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:9 → 209
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030254034.2 → XP_030109894.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X6

      Conserved Domains (1) summary
      sd00044
      Location:28 → 55
      HEAT; HEAT repeat [structural motif]

    5. XM_036164878.1 → XP_036020771.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X5

      Conserved Domains (1) summary
      sd00044
      Location:32 → 59
      HEAT; HEAT repeat [structural motif]

    6. XM_030254035.2 → XP_030109895.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X6

      Conserved Domains (1) summary
      sd00044
      Location:28 → 55
      HEAT; HEAT repeat [structural motif]

    7. XM_006496847.4 → XP_006496910.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X3

      Conserved Domains (2) summary
      sd00044
      Location:114 → 141
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:1 → 105
      PKc_like; Protein Kinases, catalytic domain

    8. XM_036164892.1 → XP_036020785.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X6

      Conserved Domains (1) summary
      sd00044
      Location:28 → 55
      HEAT; HEAT repeat [structural motif]

    9. XM_036164875.1 → XP_036020768.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X4

      Conserved Domains (2) summary
      sd00044
      Location:83 → 110
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:1 → 74
      PKc_like; Protein Kinases, catalytic domain

    10. XM_036164893.1 → XP_036020786.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X7

      Conserved Domains (1) summary
      sd00044
      Location:40 → 65
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBQ7.3 GenPept UniProtKB/Swiss-Prot:Q9DBQ7

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