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    Csnk1a1 casein kinase 1, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 93687, updated on 9-Dec-2024

    Summary

    Official Symbol
    Csnk1a1provided by MGI
    Official Full Name
    casein kinase 1, alpha 1provided by MGI
    Primary source
    MGI:MGI:1934950
    See related
    Ensembl:ENSMUSG00000024576 AllianceGenome:MGI:1934950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK1a; Csnk1a; 2610208K14Rik; 4632404G05Rik; 5430427P18Rik
    Summary
    Enables protein serine/threonine kinase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly and protein phosphorylation. Acts upstream of or within cell morphogenesis. Located in ciliary basal body and spindle. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; endocrine gland; metanephros; retina nuclear layer; and thymus primordium. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 23.9), bladder adult (RPKM 23.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Csnk1a1 in Genome Data Viewer
    Location:
    18 E1; 18 34.62 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61687307..61723391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61554236..61590320)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46637 Neighboring gene Rho guanine nucleotide exchange factor 37 Neighboring gene STARR-seq mESC enhancer starr_44745 Neighboring gene STARR-seq mESC enhancer starr_44746 Neighboring gene STARR-positive B cell enhancer ABC_E9979 Neighboring gene STARR-seq mESC enhancer starr_44748 Neighboring gene VISTA enhancer mm36 Neighboring gene STARR-seq mESC enhancer starr_44754 Neighboring gene predicted gene, 41747 Neighboring gene STARR-seq mESC enhancer starr_44755 Neighboring gene predicted gene, 35607

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC29354, MGC30571

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intermediate filament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intermediate filament cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of beta-catenin destruction complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of beta-catenin destruction complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with keratin filament ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with keratin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase I isoform alpha; casein kinase I
    Names
    CK1
    CKI-alpha
    casein kinase I-alpha
    NP_001344427.1
    NP_001344428.1
    NP_001344429.1
    NP_666199.1
    XP_006526446.1
    XP_006526449.1
    XP_011245350.1
    XP_030106505.1
    XP_030106506.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357498.1NP_001344427.1  casein kinase I isoform alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89252.1
      UniProtKB/TrEMBL
      E9Q3W1, Q3U772
      Related
      ENSMUSP00000127265.2, ENSMUST00000170862.8
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    2. NM_001357499.1NP_001344428.1  casein kinase I isoform alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89251.1
      UniProtKB/TrEMBL
      E9Q2U6, Q3U844
      Related
      ENSMUSP00000127463.2, ENSMUST00000167187.8
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    3. NM_001357500.1NP_001344429.1  casein kinase I isoform alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89254.1
      UniProtKB/Swiss-Prot
      Q3UIL0, Q64506, Q80XI2, Q8BK63, Q99LY3
      UniProtKB/TrEMBL
      Q3U772
      Related
      ENSMUSP00000132083.2, ENSMUST00000165721.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    4. NM_146087.3NP_666199.1  casein kinase I isoform alpha isoform 1

      See identical proteins and their annotated locations for NP_666199.1

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067, AK076070, AK146873, BY065893
      Consensus CDS
      CCDS37838.1
      UniProtKB/TrEMBL
      Q3U844, Q6PJ87
      Related
      ENSMUSP00000128871.2, ENSMUST00000165123.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61687307..61723391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247048.3XP_011245350.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      Q3U772
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    2. XM_006526383.4XP_006526446.1  casein kinase I isoform X2

      UniProtKB/TrEMBL
      Q3U772
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    3. XM_006526386.4XP_006526449.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      Q3U844
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    4. XM_030250645.1XP_030106505.1  casein kinase I isoform X4

      UniProtKB/TrEMBL
      Q3U772
      Related
      ENSMUSP00000127144.2, ENSMUST00000163205.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    5. XM_030250646.1XP_030106506.1  casein kinase I isoform X5

      UniProtKB/TrEMBL
      H7BXB1, Q3U844
      Related
      ENSMUSP00000110901.3, ENSMUST00000115246.9
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    RNA

    1. XR_386022.4 RNA Sequence

    2. XR_386023.4 RNA Sequence