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    Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 [ Mus musculus (house mouse) ]

    Gene ID: 110886, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gabra5provided by MGI
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit alpha 5provided by MGI
    Primary source
    MGI:MGI:95617
    See related
    Ensembl:ENSMUSG00000055078 AllianceGenome:MGI:95617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A230018I05Rik
    Summary
    Enables GABA-A receptor activity and GABA-gated chloride ion channel activity. Involved in cochlea development; inner ear receptor cell development; and innervation. Acts upstream of or within associative learning and behavioral fear response. Located in cell body and dendrite. Is expressed in brain and palatal shelf. Human ortholog(s) of this gene implicated in bipolar disorder; depressive disorder; and developmental and epileptic encephalopathy 79. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 18.3), frontal lobe adult (RPKM 16.8) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gabra5 in Genome Data Viewer
    Location:
    7 B5; 7 33.52 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (57057417..57240808, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (57407669..57591016, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor, subunit gamma 3 Neighboring gene STARR-seq mESC enhancer starr_18970 Neighboring gene vaccinia related kinase 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18971 Neighboring gene STARR-seq mESC enhancer starr_18972 Neighboring gene predicted gene, 39017 Neighboring gene predicted gene 9962 Neighboring gene STARR-seq mESC enhancer starr_18974 Neighboring gene STARR-seq mESC enhancer starr_18975 Neighboring gene STARR-seq mESC enhancer starr_18976 Neighboring gene microRNA 6389 Neighboring gene GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 Neighboring gene STARR-seq mESC enhancer starr_18977 Neighboring gene predicted gene, 34272 Neighboring gene DEP domain containing 1a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GABA-A receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GABA-A receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GABA-A receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GABA-gated chloride ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GABA-gated chloride ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GABA-gated chloride ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to benzodiazepine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cochlea development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inhibitory synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inner ear receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innervation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, GABAergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of GABA-A receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor subunit alpha-5
    Names
    GABA(A) receptor subunit alpha-5
    GABAAR subunit alpha-5
    gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
    ligand-gated ion channel subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362161.1NP_001349090.1  gamma-aminobutyric acid receptor subunit alpha-5 precursor

      Status: VALIDATED

      Source sequence(s)
      AK038476, AK083185
      Consensus CDS
      CCDS21322.1
      UniProtKB/Swiss-Prot
      Q8BHJ7
      Related
      ENSMUSP00000145685.2, ENSMUST00000206734.2
      Conserved Domains (2) summary
      TIGR00860
      Location:15449
      LIC; Cation transporter family protein
      cd19038
      Location:58256
      LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
    2. NM_001362162.1NP_001349091.1  gamma-aminobutyric acid receptor subunit alpha-5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102129, AC160553
      Consensus CDS
      CCDS21322.1
      UniProtKB/Swiss-Prot
      Q8BHJ7
      Conserved Domains (2) summary
      TIGR00860
      Location:15449
      LIC; Cation transporter family protein
      cd19038
      Location:58256
      LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
    3. NM_176942.4NP_795916.1  gamma-aminobutyric acid receptor subunit alpha-5 precursor

      See identical proteins and their annotated locations for NP_795916.1

      Status: VALIDATED

      Source sequence(s)
      AC102129, AC160553
      Consensus CDS
      CCDS21322.1
      UniProtKB/Swiss-Prot
      Q8BHJ7
      Related
      ENSMUSP00000063276.7, ENSMUST00000068456.8
      Conserved Domains (2) summary
      TIGR00860
      Location:15449
      LIC; Cation transporter family protein
      cd19038
      Location:58256
      LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      57057417..57240808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030241988.2XP_030097848.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHJ7
      Conserved Domains (2) summary
      TIGR00860
      Location:15449
      LIC; Cation transporter family protein
      cd19038
      Location:58256
      LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
    2. XM_006540560.5XP_006540623.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

      See identical proteins and their annotated locations for XP_006540623.1

      UniProtKB/Swiss-Prot
      Q8BHJ7
      Conserved Domains (2) summary
      TIGR00860
      Location:15449
      LIC; Cation transporter family protein
      cd19038
      Location:58256
      LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
    3. XM_006540557.5XP_006540620.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

      See identical proteins and their annotated locations for XP_006540620.1

      UniProtKB/Swiss-Prot
      Q8BHJ7
      Conserved Domains (2) summary
      TIGR00860
      Location:15449
      LIC; Cation transporter family protein
      cd19038
      Location:58256
      LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
    4. XM_006540556.5XP_006540619.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

      See identical proteins and their annotated locations for XP_006540619.1

      UniProtKB/Swiss-Prot
      Q8BHJ7
      Related
      ENSMUSP00000146238.2, ENSMUST00000206382.2
      Conserved Domains (2) summary
      TIGR00860
      Location:15449
      LIC; Cation transporter family protein
      cd19038
      Location:58256
      LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)