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    Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 [ Mus musculus (house mouse) ]

    Gene ID: 16514, updated on 3-Dec-2024

    Summary

    Official Symbol
    Kcnj11provided by MGI
    Official Full Name
    potassium inwardly rectifying channel, subfamily J, member 11provided by MGI
    Primary source
    MGI:MGI:107501
    See related
    Ensembl:ENSMUSG00000096146 AllianceGenome:MGI:107501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mBIR; Kir6.2
    Summary
    Enables ATP binding activity; ATP-activated inward rectifier potassium channel activity; and ankyrin binding activity. Involved in negative regulation of insulin secretion and potassium ion import across plasma membrane. Acts upstream of or within several processes, including CAMKK-AMPK signaling cascade; determination of adult lifespan; and response to ischemia. Located in T-tubule. Part of inward rectifying potassium channel. Is active in cytoplasm and plasma membrane. Is expressed in several structures, including brain; cardiovascular system; gut; skeletal muscle tissue; and testis. Used to study permanent neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 35.0), cortex adult (RPKM 10.2) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnj11 in Genome Data Viewer
    Location:
    7 B3; 7 29.66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45746545..45750215, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46097123..46100952, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nodal modulator 1 Neighboring gene predicted gene, 39010 Neighboring gene erythrocyte protein band 4.1-like 5 pseudogene Neighboring gene predicted gene, 51481 Neighboring gene ATP-binding cassette, sub-family C member 8 Neighboring gene USH1 protein network component harmonin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP-activated inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-activated inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP-activated inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled monoatomic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inward rectifier potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables potassium ion binding IC
    Inferred by Curator
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within CAMKK-AMPK signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within action potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inorganic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to resveratrol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular cardiac muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    part_of inward rectifying potassium channel IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of inward rectifying potassium channel ISO
    Inferred from Sequence Orthology
    more info
     
    part_of inward rectifying potassium channel ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-sensitive inward rectifier potassium channel 11
    Names
    inward rectifier K(+) channel Kir6.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204411.2NP_001191340.1  ATP-sensitive inward rectifier potassium channel 11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC115036
      UniProtKB/TrEMBL
      Q8CCI6
      Related
      ENSMUSP00000136002.3, ENSMUST00000180081.3
      Conserved Domains (1) summary
      cl21560
      Location:1269
      Ion_trans_2; Ion channel
    2. NM_001412604.1NP_001399533.1  ATP-sensitive inward rectifier potassium channel 11 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC115036
      UniProtKB/TrEMBL
      Q8CCI6
    3. NM_010602.4NP_034732.1  ATP-sensitive inward rectifier potassium channel 11 isoform 1

      See identical proteins and their annotated locations for NP_034732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC115036
      Consensus CDS
      CCDS21274.1
      UniProtKB/Swiss-Prot
      Q61743, Q9QX21
      UniProtKB/TrEMBL
      Q8CCI6
      Related
      ENSMUSP00000147439.2, ENSMUST00000211674.2
      Conserved Domains (2) summary
      pfam01007
      Location:36174
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:181354
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45746545..45750215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)