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    Ip6k2 inositol hexaphosphate kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 76500, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ip6k2provided by MGI
    Official Full Name
    inositol hexaphosphate kinase 2provided by MGI
    Primary source
    MGI:MGI:1923750
    See related
    Ensembl:ENSMUSG00000032599 AllianceGenome:MGI:1923750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ihpk2; 1500005N04Rik
    Summary
    Enables inositol hexakisphosphate kinase activity. Involved in inositol phosphate biosynthetic process. Acts upstream of or within positive regulation of peptidyl-serine phosphorylation and protein stabilization. Located in nucleus. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human IP6K2 (inositol hexakisphosphate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 56.3), whole brain E14.5 (RPKM 54.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ip6k2 in Genome Data Viewer
    Location:
    9 F2; 9 59.63 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108660928..108683532)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108783764..108806333)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8317 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene protein kinase, cAMP dependent regulatory, type II alpha Neighboring gene STARR-seq mESC enhancer starr_25223 Neighboring gene predicted gene, 24259 Neighboring gene STARR-seq mESC enhancer starr_25226 Neighboring gene STARR-positive B cell enhancer ABC_E2307 Neighboring gene predicted gene, 23034 Neighboring gene NCK interacting protein with SH3 domain Neighboring gene predicted gene, 35025

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP(7) metabolism in the enteric nervous system. Ito M, et al. J Biol Chem, 2023 Mar. PMID 36681123, Free PMC Article
    2. Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling. Nagpal L, et al. Proc Natl Acad Sci U S A, 2022 Apr 5. PMID 35353626, Free PMC Article
    3. Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N. Nagpal L, et al. J Neurosci, 2018 Aug 22. PMID 30006360, Free PMC Article
    4. Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Morrison BH, et al. Oncogene, 2009 Jun 25. PMID 19430495, Free PMC Article
    5. Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. Rao F, et al. Proc Natl Acad Sci U S A, 2015 Feb 10. PMID 25617365, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
      Title: The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
    2. Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling.
      Title: Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling.
    3. Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B.
      Title: Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B.
    4. IP6K2 binds selectively to the neuronal protein 4.1N. Both are highly expressed in granule cells of the cerebellum. In IP6K2 knock-out mice, IP6K2-4.1N interactions in granule cells regulate Purkinje cell morphology, the viability of cerebellar neurons, and psychomotor behavior.
      Title: Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N.
    5. IP6K2 is a major mediator of cancer cell migration and tumor metastasis, acting by enhancing cell-matrix adhesion and decreasing cell-cell adhesion.
      Title: Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.
    6. FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression.
      Title: The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade.
    7. Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
      Title: Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107719

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavonoid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavonoid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inositol hexakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to flavonoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to flavonoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inositol phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inositol phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inositol hexakisphosphate kinase 2
    Names
    insP6 kinase 2
    p(i)-uptake stimulator
    piUS
    NP_001366529.1
    NP_001366530.1
    NP_001366531.1
    NP_001366532.1
    NP_083910.2
    XP_006511914.1
    XP_006511916.1
    XP_006511917.1
    XP_006511918.1
    XP_006511919.1
    XP_036011296.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379600.1 → NP_001366529.1  inositol hexakisphosphate kinase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC168054, AC173341
      Conserved Domains (1) summary
      pfam03770
      Location:202 → 417
      IPK; Inositol polyphosphate kinase

    2. NM_001379601.1 → NP_001366530.1  inositol hexakisphosphate kinase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC168054, AC173341
      UniProtKB/Swiss-Prot
      E9QMT6, Q80V72
      Conserved Domains (1) summary
      pfam03770
      Location:225 → 440
      IPK; Inositol polyphosphate kinase

    3. NM_001379602.1 → NP_001366531.1  inositol hexakisphosphate kinase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC168054, AC173341
      Conserved Domains (1) summary
      pfam03770
      Location:202 → 417
      IPK; Inositol polyphosphate kinase

    4. NM_001379603.1 → NP_001366532.1  inositol hexakisphosphate kinase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC168054, AC173341
      UniProtKB/TrEMBL
      A0A0A6YWM3
      Related
      ENSMUSP00000141605.2, ENSMUST00000193560.6
      Conserved Domains (1) summary
      pfam03770
      Location:179 → 394
      IPK; Inositol polyphosphate kinase

    5. NM_029634.2 → NP_083910.2  inositol hexakisphosphate kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_083910.2

      Status: VALIDATED

      Source sequence(s)
      AC168054
      Consensus CDS
      CCDS23537.1
      UniProtKB/Swiss-Prot
      E9QMT6, Q80V72
      Related
      ENSMUSP00000082091.5, ENSMUST00000085018.6
      Conserved Domains (1) summary
      pfam03770
      Location:225 → 440
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108660928..108683532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511853.3 → XP_006511916.1  inositol hexakisphosphate kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_006511916.1

    2. XM_006511855.3 → XP_006511918.1  inositol hexakisphosphate kinase 2 isoform X3

    3. XM_006511856.4 → XP_006511919.1  inositol hexakisphosphate kinase 2 isoform X4

      See identical proteins and their annotated locations for XP_006511919.1

      UniProtKB/TrEMBL
      A0A0A6YXT7
      Related
      ENSMUSP00000142134.2, ENSMUST00000192307.6

    4. XM_036155403.1 → XP_036011296.1  inositol hexakisphosphate kinase 2 isoform X3

    5. XM_006511851.5 → XP_006511914.1  inositol hexakisphosphate kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006511914.1

      UniProtKB/Swiss-Prot
      E9QMT6, Q80V72
      Conserved Domains (1) summary
      pfam03770
      Location:225 → 440
      IPK; Inositol polyphosphate kinase

    6. XM_006511854.5 → XP_006511917.1  inositol hexakisphosphate kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_006511917.1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80V72.2 GenPept UniProtKB/Swiss-Prot:Q80V72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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