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    Penk preproenkephalin [ Mus musculus (house mouse) ]

    Gene ID: 18619, updated on 9-Dec-2024

    Summary

    Official Symbol
    Penkprovided by MGI
    Official Full Name
    preproenkephalinprovided by MGI
    Primary source
    MGI:MGI:104629
    See related
    Ensembl:ENSMUSG00000045573 AllianceGenome:MGI:104629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ENK; PPA; Penk1
    Summary
    Enables opioid peptide activity and opioid receptor binding activity. Involved in G protein-coupled opioid receptor signaling pathway; regulation of long-term synaptic depression; and transmission of nerve impulse. Acts upstream of or within several processes, including behavioral fear response; sensory perception of pain; and startle response. Predicted to be located in several cellular components, including cell body fiber; perikaryon; and symmetric synapse. Predicted to be active in several cellular components, including axon terminus; cytoplasmic vesicle lumen; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in overactive bladder syndrome. Orthologous to human PENK (proenkephalin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 34.5), frontal lobe adult (RPKM 32.9) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Penk in Genome Data Viewer
    Location:
    4 A1; 4 2.31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (4133536..4138815, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (4133536..4138815, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 16C, member 5 Neighboring gene STARR-seq mESC enhancer starr_09431 Neighboring gene predicted gene, 52721 Neighboring gene short chain dehydrogenase/reductase family 16C, member 6 Neighboring gene RIKEN cDNA A830012C17 gene Neighboring gene STARR-seq mESC enhancer starr_09433 Neighboring gene STARR-seq mESC enhancer starr_09434 Neighboring gene STARR-seq mESC enhancer starr_09435 Neighboring gene STARR-seq mESC enhancer starr_09436 Neighboring gene STARR-seq mESC enhancer starr_09437 Neighboring gene STARR-seq mESC enhancer starr_09438 Neighboring gene STARR-seq mESC enhancer starr_09439 Neighboring gene STARR-seq mESC enhancer starr_09440 Neighboring gene predicted gene, 33007

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables opioid peptide activity PubMed 
    enables opioid peptide activity  
    enables opioid receptor binding  
    enables opioid receptor binding PubMed 
    enables receptor ligand activity PubMed 
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway PubMed 
    acts_upstream_of_or_within aggressive behavior PubMed 
    acts_upstream_of_or_within behavioral fear response PubMed 
    involved_in cellular response to cAMP  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in cellular response to virus  
    involved_in cellular response to vitamin D  
    involved_in chemical synaptic transmission  
    involved_in general adaptation syndrome, behavioral process  
    involved_in glial cell proliferation  
    acts_upstream_of_or_within locomotory behavior PubMed 
    involved_in locomotory exploration behavior  
    involved_in locomotory exploration behavior  
    involved_in neuropeptide signaling pathway  
    involved_in neuropeptide signaling pathway  
    involved_in osteoblast differentiation  
    involved_in positive regulation of behavioral fear response  
    involved_in positive regulation of behavioral fear response  
    involved_in regulation of long-term synaptic depression PubMed 
    acts_upstream_of_or_within response to bacterium PubMed 
    involved_in response to calcium ion  
    involved_in response to epinephrine  
    involved_in response to estradiol  
    involved_in response to ethanol  
    involved_in response to ethanol  
    involved_in response to hypoxia  
    involved_in response to immobilization stress  
    involved_in response to lipopolysaccharide  
    involved_in response to nicotine  
    involved_in response to toxic substance  
    involved_in sensory perception  
    acts_upstream_of_or_within sensory perception of pain PubMed 
    involved_in signal transduction  
    acts_upstream_of_or_within startle response PubMed 
    involved_in synaptic signaling via neuropeptide  
    involved_in synaptic signaling via neuropeptide  
    involved_in transmission of nerve impulse PubMed 
    Items 1 - 25 of 38
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in axon  
    is_active_in axon terminus  
    located_in axon terminus  
    located_in axon terminus  
    located_in cell body fiber  
    located_in cell body fiber  
    located_in chromaffin granule lumen  
    is_active_in dendrite  
    located_in dendrite  
    located_in dendrite  
    located_in extracellular region  
    is_active_in neuronal cell body  
    located_in neuronal cell body  
    located_in neuronal dense core vesicle lumen  
    is_active_in neuronal dense core vesicle lumen  
    located_in perikaryon  
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in symmetric synapse  
    located_in symmetric synapse  
    located_in synaptic vesicle lumen  
    is_active_in synaptic vesicle lumen  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    proenkephalin-A
    Names
    preproenkephalin 1
    spermatogenic-specific proenkephalin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002927.4 → NP_001002927.1  proenkephalin-A precursor

      See identical proteins and their annotated locations for NP_001002927.1

      Status: VALIDATED

      Source sequence(s)
      BX004841
      Consensus CDS
      CCDS17946.1
      UniProtKB/Swiss-Prot
      P22005, Q68G73
      UniProtKB/TrEMBL
      Q3UXY8
      Related
      ENSMUSP00000066822.8, ENSMUST00000070375.8
      Conserved Domains (1) summary
      pfam01160
      Location:25 → 70
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    2. NM_001348209.2 → NP_001335138.1  proenkephalin-A precursor

      Status: VALIDATED

      Source sequence(s)
      AL732517, BX004841
      Consensus CDS
      CCDS17946.1
      UniProtKB/Swiss-Prot
      P22005, Q68G73
      UniProtKB/TrEMBL
      Q3UXY8
      Conserved Domains (1) summary
      pfam01160
      Location:25 → 70
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      4133536..4138815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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