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    Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 242285, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sdr16c5provided by MGI
    Official Full Name
    short chain dehydrogenase/reductase family 16C, member 5provided by MGI
    Primary source
    MGI:MGI:2668443
    See related
    Ensembl:ENSMUSG00000028236 AllianceGenome:MGI:2668443
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdhe2; Scdr9
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; all-trans-retinol dehydrogenase (NAD+) activity; and transcription corepressor activity. Predicted to be involved in keratinocyte proliferation; negative regulation of macromolecule biosynthetic process; and retinoid metabolic process. Predicted to be located in chromatin; endoplasmic reticulum membrane; and nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in lipid droplet. Predicted to colocalize with endoplasmic reticulum and plasma membrane. Orthologous to human SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Sdr16c5 in Genome Data Viewer
    Location:
    4 A1; 4 2.23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (3995942..4019663, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (3995942..4019663, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1, retrotransposed Neighboring gene ribosomal protein S10, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_09431 Neighboring gene predicted gene, 52721 Neighboring gene short chain dehydrogenase/reductase family 16C, member 6 Neighboring gene preproenkephalin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC124012, MGC124013

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression, epigenetic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinal metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    epidermal retinol dehydrogenase 2
    Names
    EPHD-2
    RDH-E2
    epidermal retinal dehydrogenase 2
    retSDR2
    retinal short chain dehydrogenase reductase (Rdhe2)
    retinal short chain dehydrogenase reductase 2
    short chain dehydrogenase reductase 9
    NP_871789.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181989.1NP_871789.1  epidermal retinol dehydrogenase 2

      See identical proteins and their annotated locations for NP_871789.1

      Status: PROVISIONAL

      Source sequence(s)
      AY277588
      Consensus CDS
      CCDS17944.1
      UniProtKB/Swiss-Prot
      Q7TQA3
      Related
      ENSMUSP00000046298.4, ENSMUST00000040925.4
      Conserved Domains (2) summary
      cd05339
      Location:42284
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:41231
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      3995942..4019663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)