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    MON2 Mon2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MON2
    Official Full Name
    Mon2p
    Primary source
    SGD:S000005241
    Locus tag
    YNL297C
    See related
    AllianceGenome:SGD:S000005241; FungiDB:YNL297C; VEuPathDB:YNL297C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YSL2
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in endocytosis; protein targeting to vacuole; and retrograde transport, endosome to Golgi. Located in early endosome membrane and trans-Golgi network. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MON2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (71673..76583, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene non-canonical poly(A) polymerase TRF5 Neighboring gene serine/threonine protein kinase CLA4 Neighboring gene Mrx6p Neighboring gene Rim21p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p. Jochum A, et al. Mol Cell Biol, 2002 Jul. PMID 12052896, Free PMC Article
    2. Molecular interactions of yeast Neo1p, an essential member of the Drs2 family of aminophospholipid translocases, and its role in membrane trafficking within the endomembrane system. Wicky S, et al. Mol Cell Biol, 2004 Sep. PMID 15314152, Free PMC Article
    3. Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis. Efe JA, et al. J Cell Sci, 2005 Oct 15. PMID 16219684
    4. Mon2 is a negative regulator of the monomeric G protein, Arl1. Manlandro CM, et al. FEMS Yeast Res, 2012 Sep. PMID 22594927
    5. Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex. Barbosa S, et al. Traffic, 2010 Aug. PMID 20477991

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors demonstrated that MON2 is a negative regulator of the GTP-restricted allele of ARL1 , ARL1[Q72L].
      Title: Mon2 is a negative regulator of the monomeric G protein, Arl1.
    2. Data show that Dop1p localizes to endosomes and exists in a complex with Neo1p-Ysl2p-Arl1p.
      Title: Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex.
    3. Ysl2p represents an essential, evolutionarily conserved member of a network controlling direct binding and membrane docking of Ggas..
      Title: Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution.
    4. Mon2p is a scaffold protein with novel conserved domains, and is involved in multiple aspects of endomembrane trafficking.
      Title: Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis.
    5. Dop1 plays a widespread role in membrane organization, and Mon2 acts as a scaffold to recruit the Golgi-localized pool of Dop1
      Title: Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole HMP PubMed 
    involved_in protein targeting to vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mon2p
    NP_014102.1
    • Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      71673..76583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183135.1 → NP_014102.1  TPA: Mon2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0P7, P48563
      UniProtKB/TrEMBL
      A6ZSI2, B5VQC1, C7GS58, N1NZQ9
      Conserved Domains (3) summary
      pfam16206
      Location:936 → 1161
      Mon2_C; C-terminal region of Mon2 protein
      pfam12783
      Location:202 → 362
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:8 → 176
      DCB; dimerization and cyclophilin-binding domain of Mon2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48563.1

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