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    MCH5 riboflavin transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MCH5
    Official Full Name
    riboflavin transporter
    Primary source
    SGD:S000005833
    Locus tag
    YOR306C
    See related
    AllianceGenome:SGD:S000005833; FungiDB:YOR306C; VEuPathDB:YOR306C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables riboflavin transmembrane transporter activity. Involved in riboflavin transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome; cataract 47; and intellectual disability. Orthologous to several human genes including SLC16A10 (solute carrier family 16 member 10) and SLC16A9 (solute carrier family 16 member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MCH5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (889867..891432, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bil1p Neighboring gene Rrg7p Neighboring gene Sly41p Neighboring gene U4/U6-U5 snRNP complex subunit SNU66

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The monocarboxylate transporter homolog Mch5p catalyzes riboflavin (vitamin B2) uptake in Saccharomyces cerevisiae. Reihl P, et al. J Biol Chem, 2005 Dec 2. PMID 16204239
    2. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
    3. Disruption and basic functional analysis of six novel ORFs of chromosome XV from Saccharomyces cerevisiae. Lafuente MJ, et al. Yeast, 1999 Jul. PMID 10407273
    4. Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity. Wu MJ, et al. Biometals, 2012 Jun. PMID 22403011
    5. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap AP, et al. Biochem J, 1999 Oct 15. PMID 10510291, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae
      Title: The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae.
    2. S. cerevisiae has a mechanism to sense riboflavin and avert riboflavin deficiency by increasing the expression of the plasma membrane transporter MCH5
      Title: The monocarboxylate transporter homolog Mch5p catalyzes riboflavin (vitamin B2) uptake in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables riboflavin transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in riboflavin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    riboflavin transporter
    NP_014951.4
    • Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      889867..891432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183726.4 → NP_014951.4  TPA: riboflavin transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014951.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W306, Q08777
      UniProtKB/TrEMBL
      C7GNV4, G2WNH3, N1NYX5
      Conserved Domains (1) summary
      cd17352
      Location:106 → 510
      MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08777.2

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