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    TOS2 Tos2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOS2
    Official Full Name
    Tos2p
    Primary source
    SGD:S000003453
    Locus tag
    YGR221C
    See related
    AllianceGenome:SGD:S000003453; FungiDB:YGR221C; VEuPathDB:YGR221C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maintenance of protein location in cell and negative regulation of mitotic cytokinesis. Located in cellular bud neck; cellular bud tip; and incipient cellular bud site. Is active in site of polarized growth. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOS2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (937124..938992, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene exportin CRM1 Neighboring gene mitochondrial 54S ribosomal protein YmL9 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pet54p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. Tomishige N, et al. J Gen Appl Microbiol, 2005 Oct. PMID 16314687
    2. Evidence for functional links between the Rgd1-Rho3 RhoGAP-GTPase module and Tos2, a protein involved in polarized growth in Saccharomyces cerevisiae. Claret S, et al. FEMS Yeast Res, 2011 Mar. PMID 21143383
    3. Separate membrane targeting and anchoring domains function in the localization of the S. cerevisiae Cdc24p guanine nucleotide exchange factor. Toenjes KA, et al. Curr Genet, 2004 May. PMID 14872283
    4. Genome-wide analysis of the effects of heat shock on a Saccharomyces cerevisiae mutant with a constitutively activated cAMP-dependent pathway. Jones DL, et al. Comp Funct Genomics, 2004. PMID 18629174, Free PMC Article
    5. Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae. Gandhi M, et al. Genetics, 2006 Oct. PMID 16816427, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors propose that Tos2p, a protein involved in polarized growth and most probably associated with the plasma membrane, modulates the action of Rgd1p and Rho3p in Saccharomyces cerevisiae.
      Title: Evidence for functional links between the Rgd1-Rho3 RhoGAP-GTPase module and Tos2, a protein involved in polarized growth in Saccharomyces cerevisiae.
    2. A negative regulatory function in cytokinesis is suggested for Tos2.
      Title: Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of protein location in cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud HDA PubMed 
    located_in cellular bud membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of polarized growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tos2p
    NP_011737.2
    • Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog, SKG6, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      937124..938992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181350.2 → NP_011737.2  TPA: Tos2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011737.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV03, P50078
      UniProtKB/TrEMBL
      N1P2K1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50078.2

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