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    BOI1 Boi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BOI1
    Official Full Name
    Boi1p
    Primary source
    SGD:S000000181
    Locus tag
    YBL085W
    See related
    AllianceGenome:SGD:S000000181; FungiDB:YBL085W; VEuPathDB:YBL085W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BOB1; GIN7
    Summary
    Enables phospholipid binding activity. Involved in several processes, including budding cell apical bud growth; septum digestion after cytokinesis; and vesicle fusion to plasma membrane. Located in cellular bud neck. Is active in cellular bud. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BOI1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (63876..66818)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L23A Neighboring gene uncharacterized protein Neighboring gene anaphase promoting complex subunit CDC27 Neighboring gene dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids. Hallett MA, et al. BMC Cell Biol, 2002 Jun 27. PMID 12097146, Free PMC Article
    2. A positive selection for plasmid loss in Saccharomyces cerevisiae using galactose-inducible growth inhibitory sequences. Kawahata M, et al. Yeast, 1999 Jan 15. PMID 10028180
    3. Yeast src homology region 3 domain-binding proteins involved in bud formation. Matsui Y, et al. J Cell Biol, 1996 May. PMID 8666671, Free PMC Article
    4. Associations among PH and SH3 domain-containing proteins and Rho-type GTPases in Yeast. Bender L, et al. J Cell Biol, 1996 May. PMID 8666672, Free PMC Article
    5. The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae. Liu Y, et al. Mol Microbiol, 2015 May. PMID 25708805

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
      Title: Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
    2. Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
      Title: Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
    3. evidence that the Rpd3/Sin3/Ume6 histone deacetylase complex, which represses meiotic genes during mitosis, also prevents the induction of BOI1's 5'-extended isoform in mitosis by direct binding of Ume6 to its URS1 target
      Title: The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in budding cell apical bud growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septum digestion after cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle fusion to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Boi1p
    NP_009468.1
    • Protein involved in polar growth, functionally redundant with Boi2p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      63876..66818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178325.1 → NP_009468.1  TPA: Boi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009468.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPR9, P38041
      UniProtKB/TrEMBL
      B3LNL6, C7GK50
      Conserved Domains (3) summary
      cd11886
      Location:17 → 71
      SH3_BOI; Src Homology 3 domain of fungal BOI-like proteins
      cd13316
      Location:778 → 894
      PH_Boi; Boi family Pleckstrin homology domain
      cl15755
      Location:226 → 290
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38041.1

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