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    Hdc histidine decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 15186, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hdcprovided by MGI
    Official Full Name
    histidine decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:96062
    See related
    Ensembl:ENSMUSG00000027360 AllianceGenome:MGI:96062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hdc-a; Hdc-c; Hdc-e; Hdc-s
    Summary
    Enables histidine decarboxylase activity. Acts upstream of or within L-histidine catabolic process and histamine biosynthetic process. Predicted to be located in dendrite and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Gilles de la Tourette syndrome. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 49.0), lung adult (RPKM 24.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hdc in Genome Data Viewer
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126435579..126465942, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126593659..126624025, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05604 Neighboring gene STARR-seq mESC enhancer starr_05605 Neighboring gene predicted gene, 26697 Neighboring gene STARR-seq mESC enhancer starr_05606 Neighboring gene solute carrier family 27 (fatty acid transporter), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E11157 Neighboring gene GA repeat binding protein, beta 1 Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene RIKEN cDNA A630026N12 gene Neighboring gene STARR-seq mESC enhancer starr_05607

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histidine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histidine decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histidine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histidine decarboxylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-histidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within L-histidine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-histidine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within L-histidine catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in L-histidine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in catecholamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in histamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within histamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histidine decarboxylase
    Names
    L-histidine decarboxylase
    NP_032256.3
    XP_006498847.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008230.6NP_032256.3  histidine decarboxylase

      See identical proteins and their annotated locations for NP_032256.3

      Status: VALIDATED

      Source sequence(s)
      AK133455, AV249910, BQ176022
      Consensus CDS
      CCDS16684.1
      UniProtKB/Swiss-Prot
      P23738, Q9QWU3
      UniProtKB/TrEMBL
      Q7TMW5
      Related
      ENSMUSP00000028838.5, ENSMUST00000028838.5
      Conserved Domains (1) summary
      pfam00282
      Location:43421
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      126435579..126465942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498784.4XP_006498847.1  histidine decarboxylase isoform X1

      UniProtKB/TrEMBL
      Q7TMW5
      Conserved Domains (1) summary
      pfam00282
      Location:62440
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain