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    Abcb4 ATP-binding cassette, sub-family B member 4 [ Mus musculus (house mouse) ]

    Gene ID: 18670, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcb4provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B member 4provided by MGI
    Primary source
    MGI:MGI:97569
    See related
    Ensembl:ENSMUSG00000042476 AllianceGenome:MGI:97569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mdr2; Pgy2; Pgy-2; mdr-2
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in bile acid secretion and response to fenofibrate. Located in intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple) and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 22.1), liver E18 (RPKM 18.3) and 5 other tissues See more
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    Genomic context

    See Abcb4 in Genome Data Viewer
    Location:
    5 A1; 5 3.43 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8943614..9009226)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8893614..8959226)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 1A Neighboring gene predicted gene, 31157 Neighboring gene STARR-seq mESC enhancer starr_12393 Neighboring gene predicted gene 5106 Neighboring gene ATP-binding cassette, sub-family B member 1B Neighboring gene STARR-seq mESC enhancer starr_12396 Neighboring gene STARR-seq mESC enhancer starr_12398 Neighboring gene STARR-seq mESC enhancer starr_12399 Neighboring gene STARR-positive B cell enhancer ABC_E6299 Neighboring gene calponin 3, acidic pseudogene Neighboring gene predicted gene, 31388 Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene carnitine O-octanoyltransferase Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene predicted gene, 40264

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylcholine floppase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine floppase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to bile acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to bile acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phospholipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to fenofibrate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in xenobiotic transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylcholine translocator ABCB4
    Names
    ATP-binding cassette, sub-family B (MDR/TAP), member 4
    P glycoprotein 2
    P-glycoprotein 3
    multidrug resistance protein 2
    multidrug resistance protein 3
    NP_032856.2
    XP_006503614.1
    XP_006503615.1
    XP_006503617.1
    XP_036020767.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008830.2NP_032856.2  phosphatidylcholine translocator ABCB4

      See identical proteins and their annotated locations for NP_032856.2

      Status: VALIDATED

      Source sequence(s)
      AA239419, AK050345, AK144024, CB951185, CJ071650, CX204859
      Consensus CDS
      CCDS19086.1
      UniProtKB/Swiss-Prot
      B9EK77, P21440, Q6LCL9
      Related
      ENSMUSP00000003717.9, ENSMUST00000003717.13
      Conserved Domains (3) summary
      cd03249
      Location:392628
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:301269
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:58342
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      8943614..9009226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503552.2XP_006503615.1  phosphatidylcholine translocator ABCB4 isoform X2

      Conserved Domains (1) summary
      PTZ00265
      Location:11216
      PTZ00265; multidrug resistance protein (mdr1); Provisional
    2. XM_006503551.5XP_006503614.1  phosphatidylcholine translocator ABCB4 isoform X1

      Conserved Domains (2) summary
      cd03249
      Location:392628
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:301203
      PTZ00265; multidrug resistance protein (mdr1); Provisional
    3. XM_036164874.1XP_036020767.1  phosphatidylcholine translocator ABCB4 isoform X3

      Conserved Domains (1) summary
      PTZ00265
      Location:141111
      PTZ00265; multidrug resistance protein (mdr1); Provisional
    4. XM_006503554.4XP_006503617.1  phosphatidylcholine translocator ABCB4 isoform X4

      Conserved Domains (1) summary
      PTZ00265
      Location:371052
      PTZ00265; multidrug resistance protein (mdr1); Provisional