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    MRX14 putative mitochondrial 54S ribosomal protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRX14
    Official Full Name
    putative mitochondrial 54S ribosomal protein
    Primary source
    SGD:S000002522
    Locus tag
    YDR115W
    See related
    AllianceGenome:SGD:S000002522; FungiDB:YDR115W; VEuPathDB:YDR115W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    bL34m
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion and nucleus. Orthologous to human MRPL34 (mitochondrial ribosomal protein L34). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MRX14 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (682175..682492)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene alanine transaminase ALT2 Neighboring gene securin Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein MRPL1 Neighboring gene Tma64p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial ribosome bL34 mutants present diminished translation of cytochrome c oxidase subunits. Guedes-Monteiro RF, et al. Cell Biol Int, 2018 Jun. PMID 29160602, Free PMC Article
    2. Proteomic profiling of the mitochondrial ribosome identifies Atp25 as a composite mitochondrial precursor protein. Woellhaf MW, et al. Mol Biol Cell, 2016 Oct 15. PMID 27582385, Free PMC Article
    3. The Antifungal Plant Defensin HsAFP1 from Heuchera sanguinea Induces Apoptosis in Candida albicans. Aerts AM, et al. Front Microbiol, 2011. PMID 21993350, Free PMC Article
    4. Functional discovery via a compendium of expression profiles. Hughes TR, et al. Cell, 2000 Jul 7. PMID 10929718
    5. Structure of the yeast mitochondrial large ribosomal subunit. Amunts A, et al. Science, 2014 Mar 28. PMID 24675956, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative mitochondrial 54S ribosomal protein
    NP_010400.1
    • Putative mitochondrial ribosomal protein of the large subunit; required for respiratory growth and for efficient translation of mitochondrial COX1 and COX3; conditional mutant has reduced cytochrome c oxidase activity; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress; contains and N-terminal mitochondrial targeting sequence; similar to E. coli L34 ribosomal protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      682175..682492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180423.1 → NP_010400.1  TPA: putative mitochondrial 54S ribosomal protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSA0, Q04598
      UniProtKB/TrEMBL
      A6ZY76, B3LGG2, C7GIM2, C8Z531, G2WAL6, N1P6C0
      Conserved Domains (1) summary
      pfam00468
      Location:63 → 104
      Ribosomal_L34; Ribosomal protein L34
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04598.1

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