Wnt8a wingless-type MMTV integration site family, member 8A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt8aprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 8Aprovided by MGI
Primary source: MGI:MGI:107924
See related: Ensembl:ENSMUSG00000012282 AllianceGenome:MGI:107924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wnt8d; Stra11; Wnt-8A; Wnt-8D
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including axis specification; endoderm development; and regulation of protein localization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human WNT8A (Wnt family member 8A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (34675380..34681114)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (34542327..34548061)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lncRNA Ttc3-209 Promotes the Apoptosis of Retinal Ganglion Cells in Retinal Ischemia Reperfusion Injury by Targeting the miR-484/Wnt8a Axis.
Title: lncRNA Ttc3-209 Promotes the Apoptosis of Retinal Ganglion Cells in Retinal Ischemia Reperfusion Injury by Targeting the miR-484/Wnt8a Axis.
Caudal Wnt8a is expressed only early somite stages. It is needed for normal anterior trunk development in the absence of Wnt3a. Wnt8a and Wnt3a cooperate to maintain Fgf8 expression and stop premature Sox2 up-regulation in the axial stem cell niche.
Title: Wnt8a and Wnt3a cooperate in the axial stem cell niche to promote mammalian body axis extension.
Wnt8a expression depends on the presence of Fgf3 indicating a serial regulation between Fgf and Wnt signalling during otic placode induction and specification.
Title: Roles of Wnt8a during formation and patterning of the mouse inner ear.
demonstrate that both the enlargement of the otic placode and the expansion of the Wnt8a expression domain can be rescued in Spry1/; Spry2/ embryos by reducing the gene dosage of Fgf10
Title: Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling.
FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
Title: FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
Developmental regulation of this protein is involved in cardiac myogenesis
Title: A Wnt- and beta -catenin-dependent pathway for mammalian cardiac myogenesis.
The Wnt8A expression was evaluted in the resultant Tg(CAG-mWnt8A) embryos to identify mWnt8A misexpression.
Title: Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt8a (e-PCR), detects polymorphism
- UniSTS:471331

Wnt8a (e-PCR), detects polymorphism
- UniSTS:527145

NoName (e-PCR)
- UniSTS:494957

Wnt8a (e-PCR), detects polymorphism
- UniSTS:277889

Wnt8a (e-PCR), detects polymorphism
- UniSTS:507325

NoName (e-PCR)
- UniSTS:237770

Z68889 (e-PCR)
- UniSTS:125938

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of animal organ orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within polarity specification of proximal/distal axis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-8a

Names: protein Wnt-8d; stimulated by retinoic acid gene 11 protein; wingless-related MMTV integration site 8A; wingless-related MMTV integration site 8D; wnt-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.