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    Tuba4a tubulin, alpha 4A [ Mus musculus (house mouse) ]

    Gene ID: 22145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tuba4aprovided by MGI
    Official Full Name
    tubulin, alpha 4Aprovided by MGI
    Primary source
    MGI:MGI:1095410
    See related
    Ensembl:ENSMUSG00000026202 AllianceGenome:MGI:1095410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M[a]4; Tuba4
    Summary
    Enables enzyme binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in early embryo; lung; nervous system; and retina layer. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 120.6), liver E14.5 (RPKM 60.0) and 20 other tissues See more
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    Genomic context

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    See Tuba4a in Genome Data Viewer
    Location:
    1 C4; 1 38.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75190867..75197905, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75214972..75221261, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321 Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene STARR-positive B cell enhancer ABC_E3282 Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene STARR-seq mESC enhancer starr_01353 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene protein tyrosine phosphatase receptor type N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An essential role for α4A-tubulin in platelet biogenesis. Strassel C, et al. Life Sci Alliance, 2019 Feb. PMID 30760556, Free PMC Article
    2. Loss of α4A- and β1-tubulins leads to severe platelet spherocytosis and strongly impairs hemostasis in mice. Kimmerlin Q, et al. Blood, 2022 Nov 24. PMID 36026602
    3. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. Hausrat TJ, et al. Nat Commun, 2022 Jul 20. PMID 35858909, Free PMC Article
    4. Expression patterns of Sema3A in developing amniote limbs: With reference to the diversification of peripheral nerve innervation. Noguchi K, et al. Dev Growth Differ, 2017 May. PMID 28555754
    5. Codon modification of Tuba1a alters mRNA levels and causes a severe neurodevelopmental phenotype in mice. Leca I, et al. Sci Rep, 2023 Jan 21. PMID 36681692, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin alpha-4A chain
    Names
    alpha-tubulin isotype M-alpha-4
    tubulin alpha-4 chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313723.2 → NP_001300652.1  tubulin alpha-4A chain isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166150
      Conserved Domains (1) summary
      cl25946
      Location:1 → 246
      Tubulin; Tubulin/FtsZ family, GTPase domain

    2. NM_001313724.2 → NP_001300653.1  tubulin alpha-4A chain isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166150
      UniProtKB/TrEMBL
      Q99KA2
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 295
      PTZ00335; tubulin alpha chain; Provisional

    3. NM_001420874.1 → NP_001407803.1  tubulin alpha-4A chain isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166150
      UniProtKB/TrEMBL
      Q99KA2

    4. NM_001420875.1 → NP_001407804.1  tubulin alpha-4A chain isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166150
      UniProtKB/TrEMBL
      Q3TIZ0
      Related
      ENSMUSP00000078429.8, ENSMUST00000079464.13

    5. NM_001420876.1 → NP_001407805.1  tubulin alpha-4A chain isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166150
      UniProtKB/TrEMBL
      Q3TIZ0

    6. NM_009447.5 → NP_033473.1  tubulin alpha-4A chain isoform 1

      See identical proteins and their annotated locations for NP_033473.1

      Status: VALIDATED

      Source sequence(s)
      AC166150
      Consensus CDS
      CCDS35623.1
      UniProtKB/Swiss-Prot
      P68368, Q3TY31
      UniProtKB/TrEMBL
      Q3TIZ0
      Related
      ENSMUSP00000140657.2, ENSMUST00000186213.7
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 448
      PTZ00335; tubulin alpha chain; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75190867..75197905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496478.2 → XP_006496541.1  tubulin alpha-4A chain isoform X1

      See identical proteins and their annotated locations for XP_006496541.1

      UniProtKB/TrEMBL
      Q3TIZ0
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 433
      PTZ00335; tubulin alpha chain; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68368.1 GenPept UniProtKB/Swiss-Prot:P68368

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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