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    Abcb1b ATP-binding cassette, sub-family B member 1B [ Mus musculus (house mouse) ]

    Gene ID: 18669, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcb1bprovided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B member 1Bprovided by MGI
    Primary source
    MGI:MGI:97568
    See related
    Ensembl:ENSMUSG00000028970 AllianceGenome:MGI:97568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mdr; Mdr1; Pgy1; Abcb1; Mdr1b; Pgy-1
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in adrenal adult (RPKM 39.4), placenta adult (RPKM 7.7) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Abcb1b in Genome Data Viewer
    Location:
    5 A1; 5 3.43 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8848147..8916314)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8798147..8866314)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B member 1A Neighboring gene predicted gene, 31157 Neighboring gene STARR-seq mESC enhancer starr_12393 Neighboring gene predicted gene 5106 Neighboring gene STARR-seq mESC enhancer starr_12396 Neighboring gene STARR-seq mESC enhancer starr_12398 Neighboring gene STARR-seq mESC enhancer starr_12399 Neighboring gene ATP-binding cassette, sub-family B member 4 Neighboring gene STARR-positive B cell enhancer ABC_E6299 Neighboring gene calponin 3, acidic pseudogene Neighboring gene predicted gene, 31388

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables floppase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylcholine floppase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine floppase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylcholine floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylethanolamine flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Sertoli cell barrier remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carboxylic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ceramide translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ceramide translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transepithelial transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent translocase ABCB1
    Names
    ATP-binding cassette sub-family B member 1
    ATP-binding cassette, sub-family B (MDR/TAP), member 1B
    P glycoprotein 1
    multidrug resistance protein 1
    multidrug resistance protein 1B
    phospholipid transporter ABCB1
    NP_035205.1
    XP_030110060.1
    XP_036020766.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011075.2NP_035205.1  ATP-dependent translocase ABCB1

      See identical proteins and their annotated locations for NP_035205.1

      Status: VALIDATED

      Source sequence(s)
      AK030328, AK139854, BG080311, BQ829721, BY435708, DV651684
      Consensus CDS
      CCDS19085.1
      UniProtKB/Swiss-Prot
      P06795
      UniProtKB/TrEMBL
      B2RUR3
      Related
      ENSMUSP00000009058.6, ENSMUST00000009058.10
      Conserved Domains (1) summary
      PTZ00265
      Location:551270
      PTZ00265; multidrug resistance protein (mdr1); Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      8848147..8916314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254200.2XP_030110060.1  ATP-dependent translocase ABCB1 isoform X1

      Conserved Domains (1) summary
      PTZ00265
      Location:4883
      PTZ00265; multidrug resistance protein (mdr1); Provisional
    2. XM_036164873.1XP_036020766.1  ATP-dependent translocase ABCB1 isoform X2

      UniProtKB/TrEMBL
      Q3UMH0
      Conserved Domains (2) summary
      cd03249
      Location:245484
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:2483
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]