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    Sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [ Mus musculus (house mouse) ]

    Gene ID: 20349, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sema3eprovided by MGI
    Official Full Name
    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Eprovided by MGI
    Primary source
    MGI:MGI:1340034
    See related
    Ensembl:ENSMUSG00000063531 AllianceGenome:MGI:1340034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Semah; mKIAA0331; 6430702L12
    Summary
    Enables semaphorin receptor binding activity. Involved in several processes, including angiogenesis; negative regulation of angiogenesis; and negative regulation of cell-matrix adhesion. Located in extracellular space. Is expressed in several structures, including cochlea; embryo mesenchyme; hemolymphoid system gland; nervous system; and nose. Orthologous to human SEMA3E (semaphorin 3E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 7.6), placenta adult (RPKM 3.8) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sema3e in Genome Data Viewer
    Location:
    5 A1; 5 5.66 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (14075290..14306703)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (14025276..14256689)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35702 Neighboring gene DND microRNA-mediated repression inhibitor 1, pseudogene Neighboring gene STARR-seq mESC enhancer starr_12460 Neighboring gene STARR-seq mESC enhancer starr_12461 Neighboring gene STARR-seq mESC enhancer starr_12466 Neighboring gene STARR-seq mESC enhancer starr_12467 Neighboring gene STARR-seq mESC enhancer starr_12468 Neighboring gene STARR-seq mESC enhancer starr_12469 Neighboring gene STARR-seq mESC enhancer starr_12470 Neighboring gene STARR-seq mESC enhancer starr_12471 Neighboring gene STARR-seq mESC enhancer starr_12472 Neighboring gene STARR-seq mESC enhancer starr_12473 Neighboring gene STARR-seq mESC enhancer starr_12474 Neighboring gene piccolo (presynaptic cytomatrix protein) Neighboring gene STARR-seq mESC enhancer starr_12476 Neighboring gene STARR-seq mESC enhancer starr_12477 Neighboring gene STARR-seq mESC enhancer starr_12478 Neighboring gene arginine/serine-rich coiled-coil 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12479 Neighboring gene STARR-seq mESC enhancer starr_12480 Neighboring gene predicted gene, 52805 Neighboring gene predicted gene 9758

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables semaphorin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    semaphorin-3E
    Names
    sema H
    semaphorin-H

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011348.2NP_035478.2  semaphorin-3E precursor

      See identical proteins and their annotated locations for NP_035478.2

      Status: VALIDATED

      Source sequence(s)
      AC120420, AF034744, AK141295, AK142340, BE947109
      Consensus CDS
      CCDS19093.1
      UniProtKB/Swiss-Prot
      O09078, O09079, P70275, Q9QX23
      Related
      ENSMUSP00000073612.7, ENSMUST00000073957.8
      Conserved Domains (3) summary
      cd05871
      Location:585675
      Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin
      cd11253
      Location:49519
      Sema_3E; The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E)
      smart00423
      Location:518566
      PSI; domain found in Plexins, Semaphorins and Integrins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      14075290..14306703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)