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    Zfp14 zinc finger protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 243906, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp14provided by MGI
    Official Full Name
    zinc finger protein 14provided by MGI
    Primary source
    MGI:MGI:99160
    See related
    Ensembl:ENSMUSG00000053985 AllianceGenome:MGI:99160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Krox-9; Zfp-14; mKIAA1559; 4732429I09Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within blastocyst hatching. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cranial ganglion; dorsal root ganglion; genitourinary system; and hemolymphoid system gland. Orthologous to human ZFP14 (ZFP14 zinc finger protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 3.1), CNS E18 (RPKM 2.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp14 in Genome Data Viewer
    Location:
    7 B1; 7 17.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29735782..29751664, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30036357..30051396, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31735 Neighboring gene STARR-seq mESC enhancer starr_18498 Neighboring gene zinc finger protein 568 Neighboring gene STARR-seq mESC enhancer starr_18501 Neighboring gene STARR-positive B cell enhancer ABC_E8161 Neighboring gene zinc finger protein 82 Neighboring gene STARR-seq mESC enhancer starr_18504 Neighboring gene zinc finger protein 566 Neighboring gene STARR-positive B cell enhancer ABC_E869

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster. Mohibi S, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jan 1. PMID 36349645, Free PMC Article
    2. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
    3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster.
      Title: Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Clone Names

    • KIAA1559

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 14
    Names
    zinc finger protein Krox-9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358860.1 → NP_001345789.1  zinc finger protein 14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple segments in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC149283
      Consensus CDS
      CCDS39875.1
      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Related
      ENSMUSP00000076960.8, ENSMUST00000077787.8
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    2. NM_011748.2 → NP_035878.1  zinc finger protein 14

      See identical proteins and their annotated locations for NP_035878.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK030632, AK032214, AK045631, BY128777
      Consensus CDS
      CCDS39875.1
      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    3. NM_178733.5 → NP_848848.1  zinc finger protein 14

      See identical proteins and their annotated locations for NP_848848.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK030632, AK032214, BY128777
      Consensus CDS
      CCDS39875.1
      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Related
      ENSMUSP00000146824.2, ENSMUST00000207873.2
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29735782..29751664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153086.1 → XP_036008979.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036153092.1 → XP_036008985.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    3. XM_036153085.1 → XP_036008978.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    4. XM_036153093.1 → XP_036008986.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Related
      ENSMUSP00000146913.2, ENSMUST00000207072.2
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    5. XM_030242567.2 → XP_030098427.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    6. XM_036153088.1 → XP_036008981.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    7. XM_036153090.1 → XP_036008983.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    8. XM_036153094.1 → XP_036008987.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    9. XM_036153089.1 → XP_036008982.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    10. XM_036153091.1 → XP_036008984.1  zinc finger protein 14 isoform X1

      UniProtKB/Swiss-Prot
      P10755, Q5DTW6, Q8BFZ5
      Conserved Domains (4) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10755.2 GenPept UniProtKB/Swiss-Prot:P10755

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