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    Ldhc lactate dehydrogenase C [ Mus musculus (house mouse) ]

    Gene ID: 16833, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ldhcprovided by MGI
    Official Full Name
    lactate dehydrogenase Cprovided by MGI
    Primary source
    MGI:MGI:96764
    See related
    Ensembl:ENSMUSG00000030851 AllianceGenome:MGI:96764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ldh3; Ldh-3; Ldh-x; Ldhc4; LDH-C4
    Summary
    Enables L-lactate dehydrogenase activity. Involved in pyruvate catabolic process. Acts upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate biosynthetic process from pyruvate. Located in cytoplasm and motile cilium. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human LDHC (lactate dehydrogenase C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 1111.1) See more
    Orthologs
    NEW
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    Genomic context

    See Ldhc in Genome Data Viewer
    Location:
    7 B3; 7 30.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46510687..46527571)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46861263..46878147)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18874 Neighboring gene predicted gene 5331 Neighboring gene lactate dehydrogenase A Neighboring gene predicted gene, 39011 Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene predicted gene, 39012

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-lactate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    L-lactate dehydrogenase C chain
    Names
    LDH testis subunit
    LDH-C
    lactate dehydrogenase 3, C chain, sperm specific
    lactate dehydrogenase-X
    NP_001355290.1
    NP_001355291.1
    NP_038608.1
    XP_006540742.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368361.1NP_001355290.1  L-lactate dehydrogenase C chain

      Status: VALIDATED

      Source sequence(s)
      AC090123
      Consensus CDS
      CCDS21290.1
      UniProtKB/Swiss-Prot
      P00342
      UniProtKB/TrEMBL
      Q548Z6, Q64483
      Conserved Domains (1) summary
      cd05293
      Location:19329
      LDH_1; A subgroup of L-lactate dehydrogenases
    2. NM_001368362.1NP_001355291.1  L-lactate dehydrogenase C chain

      Status: VALIDATED

      Source sequence(s)
      AC090123
      Consensus CDS
      CCDS21290.1
      UniProtKB/Swiss-Prot
      P00342
      UniProtKB/TrEMBL
      Q548Z6, Q64483
      Conserved Domains (1) summary
      cd05293
      Location:19329
      LDH_1; A subgroup of L-lactate dehydrogenases
    3. NM_013580.4NP_038608.1  L-lactate dehydrogenase C chain

      See identical proteins and their annotated locations for NP_038608.1

      Status: VALIDATED

      Source sequence(s)
      AC090123
      Consensus CDS
      CCDS21290.1
      UniProtKB/Swiss-Prot
      P00342
      UniProtKB/TrEMBL
      Q548Z6, Q64483
      Related
      ENSMUSP00000014545.5, ENSMUST00000014545.11
      Conserved Domains (1) summary
      cd05293
      Location:19329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46510687..46527571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540679.1XP_006540742.1  L-lactate dehydrogenase C chain isoform X1

      See identical proteins and their annotated locations for XP_006540742.1

      UniProtKB/Swiss-Prot
      P00342
      UniProtKB/TrEMBL
      Q548Z6, Q64483
      Conserved Domains (1) summary
      cd05293
      Location:19329
      LDH_1; A subgroup of L-lactate dehydrogenases